INT208539

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.76
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnas) endosome (Gnas) signal transduction (Gnas)
extracellular region (Gnas) plasma membrane (Gnas) GTPase activity (Gnas)
Anatomy Link Frequency
neuronal 2
skeletal muscles 2
Gnas (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 20 98.88 Very High Very High Very High
Nucleus accumbens 22 69.80 Quite High
Central nervous system 1 50.48 Quite High
imagery 3 30.48 Quite Low
antagonist 11 19.36 Low Low
Pyramidal cell 10 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Huntington's Chorea 5 100.00 Very High Very High Very High
Toxicity 5 99.76 Very High Very High Very High
Injury 43 99.48 Very High Very High Very High
Muscular Dystrophy 15 95.12 Very High Very High Very High
Apoptosis 18 93.00 High High
Disease 41 90.96 High High
Tremor 5 87.12 High High
Targeted Disruption 14 77.28 Quite High
Cerebellar Diseases 1 75.52 Quite High
Retina Disease 4 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, immunocytochemistry showed expression of P2X7 and active caspase 3 at GSA-positive cells after injury without agonist application.
Positive_regulation (active) of Neg (without) Gene_expression (positive) of GSA associated with injury and agonist
1) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.81 Pain Relevance 0.15
A transversion at nucleotide 1381 of exon 6 and a C?
Positive_regulation (transversion) of Gene_expression (transversion) of exon
2) Confidence 0.02 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 0.09 Pain Relevance 0
ESOs have been shown to promote skipping of exon 23 and concomitant dystrophin expression in skeletal muscles of mdx mice after both local and systemic delivery [8,11-17], and this technology in the context of therapy for DMD has been recently reviewed [18,19].
Positive_regulation (promote) of Gene_expression (expression) of exon in skeletal muscles associated with muscular dystrophy
3) Confidence 0.01 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0.63 Pain Relevance 0
Lithium chloride treatment reduced toxicity induced by overexpression of Huntington disease exon 1 fragment with 74 glutamines in neuronal and non-neuronal cell lines [11], and attenuated toxicity of the N-terminal part of mutant huntingtin with 120 glutamine repeats in Drosophila [39].
Positive_regulation (overexpression) of Gene_expression (overexpression) of exon in neuronal associated with toxicity and huntington's chorea
4) Confidence 0.01 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 1.23 Pain Relevance 0.03

General Comments

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