INT208547

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.85
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Siglec1) cell adhesion (Siglec1) plasma membrane (Siglec1)
Anatomy Link Frequency
neuronal 2
fibroblasts 2
Siglec1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 98.80 Very High Very High Very High
b2 receptor 1 98.38 Very High Very High Very High
depression 36 84.08 Quite High
nMDA receptor 53 80.80 Quite High
Hippocampus 75 79.84 Quite High
midbrain 4 79.16 Quite High
antagonist 5 50.00 Quite Low
bradykinin 75 5.00 Very Low Very Low Very Low
long-term potentiation 22 5.00 Very Low Very Low Very Low
Dopamine 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 317 99.70 Very High Very High Very High
Stress 113 98.94 Very High Very High Very High
INFLAMMATION 24 98.80 Very High Very High Very High
Targeted Disruption 249 92.72 High High
Death 44 84.08 Quite High
Depression 36 84.08 Quite High
Anxiety Disorder 48 67.68 Quite High
Neurodegenerative Disease 106 64.24 Quite High
Down Syndrome 16 60.08 Quite High
Toxicity 20 50.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of GluR1 at Ser 831 and Ser 845 sites is important for GluR1 trafficking [50].
Positive_regulation (important) of Phosphorylation (Phosphorylation) of Ser
1) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.20 Pain Relevance 0.24
Phosphorylation of a-Syn Ser-129 in a Cell-free System Attenuates a-Syn Modulatory Effects on PP2A and TH
Positive_regulation (-) of Phosphorylation (Phosphorylation) of Ser
2) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.07
either directly or indirectly by activating Akt, thus leading to increased Ser9 phosphorylation and consequent inactivation of the kinase.
Positive_regulation (leading) of Phosphorylation (phosphorylation) of Ser9
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.67 Pain Relevance 0.13
either directly or indirectly by activating Akt, thus leading to increased Ser9 phosphorylation and consequent inactivation of the kinase.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Ser9
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.66 Pain Relevance 0.13
There are two major pathways by which lithium is known to affect the activities of multiple transcription factors that control gene expression, and both of these pathways involve inhibitory effects on GSK3: lithium can act as a competitive inhibitor of Mg2+, thereby reducing GSK3 activity [14]; lithium also inhibits GSK3 by increasing the inhibitory phosphorylation of a Ser-9 residue in GSK3?
Positive_regulation (increasing) of Phosphorylation (phosphorylation) of Ser-9
5) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.11 Pain Relevance 0
Chronic administration of lithium to mice has been shown to cause an increase in the phosphorylation of Ser-9 of GSK3?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Ser-9
6) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0 Pain Relevance 0
However, a slight increase of Ser9 phosphorylation was observed after 2 h of MPP+ treatment in primary cultures of neuronal cells (Figure 1C).


Positive_regulation (increase) of Phosphorylation (phosphorylation) of Ser9 in neuronal
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.25 Pain Relevance 0
We postulated a unique molecular signature of dysfunctional activity profiles in AD-relevant signaling pathways in peripheral tissues, based on a gain of function in G-protein-coupled bradykinin B2 receptor (BKB2R) inflammatory stress signaling in skin fibroblasts from AD patients that results in tau protein Ser hyperphosphorylation.
Positive_regulation (results) of Phosphorylation (hyperphosphorylation) of Ser in fibroblasts associated with stress, inflammation, b2 receptor and disease
8) Confidence 0.00 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2644820 Disease Relevance 1.95 Pain Relevance 0.23

General Comments

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