INT208549

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.67
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Icmt) endoplasmic reticulum (Icmt)
Anatomy Link Frequency
cerebellum 2
Icmt (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 45 97.88 Very High Very High Very High
depression 5 25.00 Low Low
Hippocampus 20 23.40 Low Low
Glutamate 10 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
amygdala 5 5.00 Very Low Very Low Very Low
excitatory amino acid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 60 98.04 Very High Very High Very High
Spinocerebellar Ataxia Type 2 235 97.96 Very High Very High Very High
Toxicity 25 96.36 Very High Very High Very High
Cancer 136 95.84 Very High Very High Very High
Neuroblastoma 126 93.44 High High
Disease 158 90.96 High High
Cognitive Disorder 45 87.56 High High
Apoptosis 18 71.60 Quite High
Neurodegenerative Disease 35 53.00 Quite High
Necrosis 2 26.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Densitometric analysis of the blots from four independent experiments revealed Icmt/Pccmt expression to be significantly elevated in lithium-treated knock-in mice (10–28 weeks of age) in comparison with the untreated knock-in littermates (p = 0.024 by t-test, Figure 5B, right column).
Gene_expression (expression) of Pccmt associated with targeted disruption
1) Confidence 0.74 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.69 Pain Relevance 0
In order to confirm that alterations in expression of Icmt/Pccmt occur in the Sca1154Q/2Q mice as well, we examined Icmt/Pccmt mRNA expression in the cerebellum of Sca1154Q/2Q and wild-type mice by Northern analysis (Figure 5).
Spec (examined) Gene_expression (expression) of Pccmt in cerebellum
2) Confidence 0.64 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.64 Pain Relevance 0
We also report that lithium treatment restored the levels of isoprenylcysteine carboxyl methyltransferase (Icmt; alternatively, Pccmt), down-regulation of which is an early marker of mutant ATXN1 toxicity.


Gene_expression (levels) of isoprenylcysteine carboxyl methyltransferase associated with toxicity
3) Confidence 0.57 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1880853 Disease Relevance 1.06 Pain Relevance 0.05
In order to confirm that alterations in expression of Icmt/Pccmt occur in the Sca1154Q/2Q mice as well, we examined Icmt/Pccmt mRNA expression in the cerebellum of Sca1154Q/2Q and wild-type mice by Northern analysis (Figure 5).
Gene_expression (expression) of Pccmt in cerebellum
4) Confidence 0.57 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.64 Pain Relevance 0
Expression of ICMT, THAP3, CAMTA1, ACOT7, KCNAB2, RPL22, and KLHL21 had weaker associations and/or associations with fewer variables (two to seven variables).
Gene_expression (Expression) of ICMT
5) Confidence 0.40 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.58 Pain Relevance 0
In addition, we have shown that the expression of the Icmt/Pccmt gene, whose down-regulation is an early marker of SCA1 pathology, is elevated after lithium treatment in Sca1154Q/2Q mice.
Gene_expression (expression) of Pccmt associated with spinocerebellar ataxia type 2
6) Confidence 0.25 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.38 Pain Relevance 0.05
Twelve of the 23 genes from the SRD were present on these chips (AJAP1, NPHP4 KCNAB2, CHD5, RPL22, ICMT, ACOT7, HES2, TNFRSF25, KLHL21, THAP3, and CAMT1).
Gene_expression (present) of ICMT
7) Confidence 0.17 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.68 Pain Relevance 0

General Comments

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