INT208552

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.80
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
MDA-MB-231 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
depression 7 97.60 Very High Very High Very High
nMDA receptor 1 96.16 Very High Very High Very High
rheumatoid arthritis 10 90.64 High High
Hippocampus 7 83.36 Quite High
Pyramidal cell 10 80.72 Quite High
Central nervous system 7 80.60 Quite High
Kinase C 14 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 15 100.00 Very High Very High Very High
Cancer 20 98.28 Very High Very High Very High
Depression 7 97.60 Very High Very High Very High
Spinocerebellar Ataxia Type 2 47 93.76 High High
Rheumatoid Arthritis 10 90.64 High High
Adhesions 2 83.56 Quite High
Disease 99 78.56 Quite High
Breast Cancer 10 75.00 Quite High
Cognitive Disorder 9 72.68 Quite High
Drug Induced Neurotoxicity 12 61.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lithium has been reported to exert its neuroprotective effects predominantly by inhibiting apoptosis through inhibition of GSK3?
Negative_regulation (inhibiting) of Negative_regulation (inhibition) of GSK3 associated with apoptosis
1) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.52 Pain Relevance 0.04
with lithium chloride or the GSK3 inhibitor BIO and GSK3?
Negative_regulation (chloride) of Negative_regulation (inhibitor) of GSK3
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2650783 Disease Relevance 0.52 Pain Relevance 0.05
Remarkably, N-cadherin, which is endogenously expressed by these cell-lines and not by MDA-MB-231 cells, was unaffected by LiCl, strongly indicating that inhibition of GSK3?
Negative_regulation (indicating) of Negative_regulation (inhibition) of GSK3 in MDA-MB-231
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650783 Disease Relevance 0.05 Pain Relevance 0
They found that a variety of inhibitors of GSK-3?
Negative_regulation (variety) of Negative_regulation (inhibitors) of GSK-3
4) Confidence 0.06 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.70 Pain Relevance 0.35

General Comments

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