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Context Info
Confidence 0.80
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.42
Pain Relevance 0.36

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protein targeting (YWHAQ) nucleolus (YWHAQ) nucleus (YWHAQ)
protein complex (YWHAQ) cytoplasm (YWHAQ)
YWHAQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 7 96.96 Very High Very High Very High
Inflammation 14 94.56 High High
Pyramidal cell 21 92.32 High High
anesthesia 1 80.64 Quite High
cINOD 10 57.80 Quite High
aspirin 1 12.00 Low Low
diclofenac 1 10.20 Low Low
Dopamine 10 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 157 99.52 Very High Very High Very High
Targeted Disruption 34 99.30 Very High Very High Very High
Stroke 1 99.20 Very High Very High Very High
Neurodegenerative Disease 24 97.32 Very High Very High Very High
INFLAMMATION 17 94.56 High High
Amyloid Plaque 20 93.72 High High
Disease 307 92.92 High High
Syndrome 7 89.76 High High
Dementia 76 89.36 High High
Alzheimer's Dementia 57 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated Tau Protein in DLB CSFSince hyperphosphorylated tau protein occurs in neurodegenerative disorders associated with neurofibrillary pathology, it is not surprising that phosphorylated tau epitopes, for example, threonine 231 (p-tau231), threonine 181 (p-tau181), and serine 199 (p-tau199), have been recommended by a consensus group as promising biomarkers to differentiate AD from other dementias, provided that they have a sensitivity level of 85% or greater and a specificity level of at least 75% [89].
Phosphorylation (Phosphorylated) of Tau associated with parkinson's disease, dementia, disease and neurodegenerative disease
1) Confidence 0.80 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.28 Pain Relevance 0
Emamian et al. [7] demonstrated that serine 776 (S776) in ataxin 1 (ATXN1) is essential for its pathogenicity in transgenic mice; Chen et al. [8] showed that phosphorylation of this residue by Akt enables 14-3-3 to interact with and stabilize ATXN1.
Phosphorylation (phosphorylation) of 14-3-3 associated with targeted disruption
2) Confidence 0.61 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 1.03 Pain Relevance 0.08
At this late time-point, we also observed increased phosphorylation of endogenous mouse protein Tau, particularly at residues T181 and T231, both known to be substrate for GSK3.
Phosphorylation (phosphorylation) of protein Tau
3) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.60 Pain Relevance 0.17
inhibitory effect [82], through which hyperphosphorylated tau protein is reduced and, in fact, less neurofibrillary tangles have been reported in patients who have previously taken statins [83].
Phosphorylation (hyperphosphorylated) of tau protein
4) Confidence 0.01 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.51 Pain Relevance 0.11

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