INT208554

Context Info Confidence 0.32 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.04 Pain Relevance 0.08

cytoplasm (YWHAQ, YWHAQ, Akt1) nucleus (YWHAQ, YWHAQ, Akt1) protein complex (YWHAQ, YWHAQ) nucleolus (YWHAQ, YWHAQ) protein targeting (YWHAQ, YWHAQ) transport (Akt1)

YWHAQ (Homo sapiens) YWHAQ (Homo sapiens) Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 81.60 Pyramidal cell 9 5.00 Hippocampus 4 5.00 Glutamate 2 5.00 Central nervous system 1 5.00 long-term potentiation 1 5.00 depression 1 5.00 ischemia 1 5.00 amygdala 1 5.00 excitatory amino acid 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 12 99.30 Disease 30 92.92 Spinocerebellar Ataxia Type 2 47 88.04 Frailty 4 80.40 Cognitive Disorder 9 74.76 Neurodegenerative Disease 7 66.96 Anxiety Disorder 12 5.00 Toxicity 5 5.00 Tremor 5 5.00 Huntington's Chorea 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Emamian et al. [7] demonstrated that serine 776 (S776) in ataxin 1 (ATXN1) is essential for its pathogenicity in transgenic mice; Chen et al. [8] showed that phosphorylation of this residue by Akt enables 14-3-3 to interact with and stabilize ATXN1.

Phosphorylation (phosphorylation) of 14-3-3 Positive_regulation (enables) of 14-3-3 Binding (interact) of Akt associated with targeted disruption

1) Confidence 0.32 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 1.04 Pain Relevance 0.08

General Comments

This test has worked.