INT208559

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.58
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
ruga 2
zymogenic cell 2
placode 2
corpus 1
parietal cells 1
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 98.96 Very High Very High Very High
antagonist 10 90.80 High High
Somatostatin 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
peptic ulcer disease 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 99.60 Very High Very High Very High
Retinal Neovascularization 1 99.16 Very High Very High Very High
INFLAMMATION 12 98.96 Very High Very High Very High
Recurrence 2 95.52 Very High Very High Very High
Fistula 71 79.88 Quite High
Cancer 3 79.40 Quite High
Polyhydramnios 3 76.80 Quite High
Apoptosis 3 68.80 Quite High
Congenital Anomalies 17 68.72 Quite High
Injury 7 52.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aetiology is largely unknown and is likely to be multifactorial, however, various clues have been uncovered in animal experiments particularly defects in the expression of the gene Sonic hedgehog (Shh).
Negative_regulation (defects) of Gene_expression (expression) of Sonic hedgehog
1) Confidence 0.43 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1884133 Disease Relevance 0.47 Pain Relevance 0
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Negative_regulation (inhibition) of Gene_expression (target) of Shh associated with hypoxia and retinal neovascularization
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.33 Pain Relevance 0
Of note, Shh expression is turned on only lately during formation of this primitive ruga, since it was always found associated with clear thickened epithelium.
Negative_regulation (turned) of Gene_expression (expression) of Shh in ruga
3) Confidence 0.41 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.07 Pain Relevance 0
Of note, such mechanisms have been classically involved in spacing of other ectodermal organs, such as hair and feather [29-31], and they are followed by Shh expression in the newly formed placode [8].
Negative_regulation (followed) of Gene_expression (expression) of Shh in placode
4) Confidence 0.41 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0.05
Prolonged colonization by H. pylori has been reported to cause extension of the inflammation from the antrum to the corpus of the stomach, with loss of Shh expression which correlated with the loss of parietal cells [21, 22].
Negative_regulation (loss) of in corpus Gene_expression (expression) of Shh in parietal cells associated with inflammation
5) Confidence 0.18 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.24 Pain Relevance 0.09
The H2R-null mice exhibited higher gastric pH, reduced Shh expression and impaired mucous neck-to-zymogenic cell differentiation.
Negative_regulation (reduced) of Gene_expression (expression) of Shh in zymogenic cell
6) Confidence 0.18 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.17 Pain Relevance 0.09
These results suggest that suppressed gastric acid secretion alone may be sufficient to down-regulate Shh expression.
Negative_regulation (down) of Gene_expression (expression) of Shh
7) Confidence 0.13 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.15 Pain Relevance 0.07
These results suggest that suppressed gastric acid secretion alone may be sufficient to down-regulate Shh expression.
Negative_regulation (regulate) of Gene_expression (expression) of Shh
8) Confidence 0.13 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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