INT208560

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 2.22
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
fibroblasts 2
cornea 2
corneal epithelial cells 2
tube 1
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 48 73.64 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
vagus nerve 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 9 99.60 Very High Very High Very High
Retinal Neovascularization 8 99.16 Very High Very High Very High
Fistula 71 95.20 Very High Very High Very High
Congenital Anomalies 13 87.48 High High
Injury 56 81.12 Quite High
Burns 48 80.24 Quite High
Cancer 24 79.40 Quite High
Apoptosis 1 54.28 Quite High
Syndrome 3 50.40 Quite High
Bacterial Infection 8 38.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed later, blocking endogenous Shh by cyclopamine attenuated NV formation in a mouse cornea.
Negative_regulation (blocking) of Shh in cornea
1) Confidence 0.59 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.08 Pain Relevance 0
In the present study of a mouse cornea, blocking Shh signaling might directly affect the cells involved in NV tissue because blocking Shh signaling by using cyclopamine does not affect the expression level of VEGF in cultured corneal epithelial cells and fibroblasts.
Negative_regulation (blocking) of Shh in corneal epithelial cells
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.26 Pain Relevance 0
Further addition of cyclopamine at 2.5 mM and 10.0 mM significantly suppressed Shh-induced vessel-like tube formation as evaluated by its total length (Figure 2).
Negative_regulation (suppressed) of Shh in tube
3) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.11 Pain Relevance 0.04
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Negative_regulation (inhibition) of Shh associated with hypoxia and retinal neovascularization
4) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.33 Pain Relevance 0
These results finally led us to hypothesize that blocking Shh signaling might have a beneficial inhibitory effect on NV development in the cornea.
Negative_regulation (blocking) of Shh in cornea
5) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.19 Pain Relevance 0
In the present study of a mouse cornea, blocking Shh signaling might directly affect the cells involved in NV tissue because blocking Shh signaling by using cyclopamine does not affect the expression level of VEGF in cultured corneal epithelial cells and fibroblasts.
Negative_regulation (blocking) of Shh in corneal epithelial cells
6) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.25 Pain Relevance 0
In the mouse, loss of function mutations of Shh and other members of its signalling pathway (Gli2, Gli3 & Foxf1) lead to tracheooesophageal malformations including OA/TOF [29].
Negative_regulation (loss) of Shh associated with fistula
7) Confidence 0.42 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1884133 Disease Relevance 0.51 Pain Relevance 0
In the present study of a mouse cornea, blocking Shh signaling might directly affect the cells involved in NV tissue because blocking Shh signaling by using cyclopamine does not affect the expression level of VEGF in cultured corneal epithelial cells and fibroblasts.
Negative_regulation (blocking) of Shh in fibroblasts
8) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.25 Pain Relevance 0
In the present study of a mouse cornea, blocking Shh signaling might directly affect the cells involved in NV tissue because blocking Shh signaling by using cyclopamine does not affect the expression level of VEGF in cultured corneal epithelial cells and fibroblasts.
Negative_regulation (blocking) of Shh in fibroblasts
9) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.26 Pain Relevance 0

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