INT208561

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 51
Total Number 54
Disease Relevance 9.57
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
cornea 12
ruga 5
parietal cells 2
stroma 1
mesenchyme 1
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 40 99.84 Very High Very High Very High
Dopamine 169 99.48 Very High Very High Very High
cytokine 126 99.16 Very High Very High Very High
Inflammation 32 98.80 Very High Very High Very High
antagonist 31 90.32 High High
Action potential 8 86.56 High High
chemokine 4 74.32 Quite High
agonist 26 67.92 Quite High
Demyelination 2 65.08 Quite High
anesthesia 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Holoprosencephaly 8 99.92 Very High Very High Very High
Ganglion Cysts 24 99.60 Very High Very High Very High
Targeted Disruption 20 99.52 Very High Very High Very High
Burns 127 99.28 Very High Very High Very High
INFLAMMATION 30 98.80 Very High Very High Very High
Cleidocranial Dysplasia 31 98.72 Very High Very High Very High
Injury 149 98.08 Very High Very High Very High
Hypoxia 27 97.22 Very High Very High Very High
Retinal Neovascularization 21 96.78 Very High Very High Very High
Corneal Neovascularization 126 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Shh expression was more marked in the area of stroma with neovascularization.


Gene_expression (expression) of Shh in stroma
1) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.33 Pain Relevance 0
The exact mechanism of upregulation of Shh expression in a healing, injured cornea needs to be explored.
Gene_expression (expression) of Shh in cornea
2) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.18 Pain Relevance 0
We have reported that the healing corneal epithelium following debridement express Shh [14], suggesting that activation of cells upon injury might switch on its expression.
Gene_expression (express) of Shh in corneal epithelium associated with injury
3) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.19 Pain Relevance 0
We then examined if Shh is expressed in a post-alkali burned, neovascularized, healing corneal stroma and if exogenous Shh promotes NV formation in a rat cornea.
Gene_expression (expressed) of Shh in cornea
4) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.15 Pain Relevance 0
The expression level of Ptc, the Shh receptor, did not change during healing in an alkali-burned cornea.
Gene_expression (expression) of Shh receptor in cornea
5) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.07 Pain Relevance 0
As previously reported by us [14], Shh was not detected in the corneal stroma of an uninjured cornea (data not shown) but was upregulated in both the healing epithelium and stroma (Figure 5A,C,E) until day 20.
Neg (not) Gene_expression (detected) of Shh in corneal stroma
6) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.33 Pain Relevance 0
A precise ventral-to-dorsal switch in foregut Shh expression is itself propagated cranially, ahead of tracheooesophageal separation [24].
Gene_expression (expression) of Shh in foregut
7) Confidence 0.77 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1884133 Disease Relevance 0.22 Pain Relevance 0
In the Adriamycin model, failure of tracheooesophageal separation is associated with disturbance of the temporospatial pattern of Shh expression [24].
Gene_expression (expression) of Shh
8) Confidence 0.77 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1884133 Disease Relevance 0.38 Pain Relevance 0
This process is associated with a precise temporospatial pattern of expression of the key developmental gene Sonic hedgehog (Shh) and members of its signalling cascade.
Gene_expression (expression) of Shh
9) Confidence 0.77 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1884133 Disease Relevance 0.20 Pain Relevance 0
The aetiology is largely unknown and is likely to be multifactorial, however, various clues have been uncovered in animal experiments particularly defects in the expression of the gene Sonic hedgehog (Shh).
Gene_expression (expression) of Shh
10) Confidence 0.77 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1884133 Disease Relevance 0.47 Pain Relevance 0
The aetiology is largely unknown and is likely to be multifactorial, however, various clues have been uncovered in animal experiments particularly defects in the expression of the gene Sonic hedgehog (Shh).
Gene_expression (expression) of Sonic hedgehog
11) Confidence 0.77 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1884133 Disease Relevance 0.46 Pain Relevance 0
Of note, Shh expression is turned on only lately during formation of this primitive ruga, since it was always found associated with clear thickened epithelium.
Gene_expression (expression) of Shh in ruga
12) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.07 Pain Relevance 0
As many other mesenchymal-epithelial organs, palatal rugae show Shh expression at an early stage of their development [23].
Gene_expression (expression) of Shh
13) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
Moreover FGF10 beads can induce ectopic Shh expression, and Fgf10 knock-out mice lack rugae [10].
Gene_expression (expression) of Shh associated with targeted disruption
14) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.10 Pain Relevance 0
This pattern closely resembled that seen through Shh expression in a littermate embryo of similar weight (Fig. 3F).
Gene_expression (expression) of Shh in embryo
15) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
Of note, such mechanisms have been classically involved in spacing of other ectodermal organs, such as hair and feather [29-31], and they are followed by Shh expression in the newly formed placode [8].
Gene_expression (expression) of Shh in placode
16) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0.05
As previously mentioned, FGF signaling (from mesenchyme) probably participates in the induction and/or maintenance of Shh expression [10].
Gene_expression (expression) of Shh in mesenchyme
17) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
Later on, Shh and Bmp7 become expressed at the tip of the newly formed ruga, and a true gap is formed.
Gene_expression (expressed) of Shh in ruga
18) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
Indeed, epithelial FGFR2b is supposed to be activated by mesenchymal FGF10 and is necessary for Shh expression in rugae [10].
Gene_expression (expression) of Shh
19) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.09 Pain Relevance 0
Based on our data and by analogy with hair and feathers, we propose that activation-inhibition mechanisms are involved in positioning new rugae during the interposition process, which finally express Shh.
Gene_expression (express) of Shh in hair
20) Confidence 0.74 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0.04

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