INT208572

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.20
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
plasma membrane (CXCR1) intracellular (IL8) signal transducer activity (CXCR1)
Anatomy Link Frequency
leukocyte 2
osteoclast 1
glandular epithelial cell 1
IL8 (Homo sapiens)
CXCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 19 100.00 Very High Very High Very High
chemokine 246 99.96 Very High Very High Very High
endometriosis 70 97.28 Very High Very High Very High
cytokine 78 94.24 High High
Arthritis 6 93.72 High High
opioid receptor 19 86.24 High High
rheumatoid arthritis 12 86.12 High High
antagonist 19 82.00 Quite High
MU agonist 8 77.04 Quite High
Multiple sclerosis 4 72.04 Quite High
Disease Link Frequency Relevance Heat
Choristoma 8 98.44 Very High Very High Very High
Endometriosis 81 97.28 Very High Very High Very High
Arthritis 6 93.72 High High
Osteolysis 16 88.48 High High
Cancer 161 86.20 High High
Rheumatoid Arthritis 12 86.12 High High
Metastasis 109 83.84 Quite High
Osteoporosis 45 81.44 Quite High
Stomach Cancer 4 74.00 Quite High
Cyst 3 72.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only CXCL-8/IL-8 and CXCL-6 specifically bind to CXCR1 whereas all ELR+CXC chemokines bind to CXCR2.
IL-8 Binding (bind) of CXCR1 associated with chemokine
1) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.68 Pain Relevance 0.33
Only CXCL-8/IL-8 and CXCL-6 specifically bind to CXCR1 whereas all ELR+CXC chemokines bind to CXCR2.
CXCL-8 Binding (bind) of CXCR1 associated with chemokine
2) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.68 Pain Relevance 0.33
The closely related CXCR1 and CXCR2 receptors [14] share a common agonist ligand in IL-8 (interleukin 8; also called CXCL8).
IL-8 Binding (ligand) of CXCR1 associated with agonist
3) Confidence 0.25 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.14 Pain Relevance 0.68
Furthermore, glandular epithelial cell localisation and upregulation of immunoreactive CXCR1 and CXCR2, which bind CXCL8, has been demonstrated in eutopic and ectopic tissue sections from endometriosis patients when compared to controls [54].
CXCL8 Binding (bind) of CXCR1 in glandular epithelial cell associated with choristoma and endometriosis
4) Confidence 0.20 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.05 Pain Relevance 0.61
IL-8/CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte chemotaxis such as polymorphonuclear neutrophils and specific T cells [41, 42].
CXCL8 Binding (ligand) of CXCR1 in leukocyte associated with chemokine
5) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.63 Pain Relevance 0.52
IL-8/CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte chemotaxis such as polymorphonuclear neutrophils and specific T cells [41, 42].
IL-8 Binding (ligand) of CXCR1 in leukocyte associated with chemokine
6) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.63 Pain Relevance 0.52
Bendre and coworkers [47] demonstrated that IL-8 binds to CXCR1 present on osteoclast precursors and enhances osteoclast differentiation independent of RANKL.
IL-8 Binding (binds) of CXCR1 in osteoclast
7) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.40 Pain Relevance 0.08

General Comments

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