INT208591

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
blood 2
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 70 98.72 Very High Very High Very High
rheumatoid arthritis 49 93.56 High High
chemokine 113 90.72 High High
Inflammatory mediators 3 50.00 Quite Low
Inflammation 27 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 81 98.72 Very High Very High Very High
Rheumatoid Arthritis 49 93.56 High High
INFLAMMATION 33 50.00 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Choristoma 8 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Reprotox - General 3 4 5.00 Very Low Very Low Very Low
Cyst 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These combined data clearly show that the expression of CCL16 and CCL21 is disturbed at least in some patients with endometriosis.
Negative_regulation (disturbed) of Gene_expression (expression) of CCL21 associated with endometriosis
1) Confidence 0.40 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.69 Pain Relevance 0.48
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Negative_regulation (downregulation) of Gene_expression (expression) of CCL21 mRNA in blood
2) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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