INT208607

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.44
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nmbr) cytoplasm (Nmbr) signal transducer activity (Nmbr)
Anatomy Link Frequency
sensory neurons 1
neurons 1
cochlear hair cells 1
Nmbr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 30 99.96 Very High Very High Very High
conotoxin 18 95.44 Very High Very High Very High
Mechanotransduction 42 90.40 High High
nociceptor 96 79.76 Quite High
Pain 78 79.00 Quite High
low threshold mechanoreceptor 48 78.48 Quite High
addiction 6 68.28 Quite High
Mechanosensation 36 60.44 Quite High
qutenza 84 57.40 Quite High
action potential duration 6 30.76 Quite Low
Disease Link Frequency Relevance Heat
Nociception 48 88.24 High High
Rheumatoid Arthritis 120 84.00 Quite High
Pain 78 79.00 Quite High
Ganglion Cysts 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biotinylated NMB-1 was synthesized using orthogonal Cys(Acm)/Cys(Trt) protection and biotinylation completed on the resin.
Gene_expression (synthesized) of NMB-1
1) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0 Pain Relevance 0
Subsequently, peptides closely related to NMB-1 were screened individually but NMB-1 produced the highest level of blockade.


Gene_expression (produced) of NMB-1
2) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0 Pain Relevance 0.05
Given the selectivity of NMB-1 for SA currents in DRG it was surprising to find that it also inhibited rapid FM1-43 uptake by cochlear hair cells; a process mediated by the mechanotransducing ion channels of these cells.
Gene_expression (selectivity) of NMB-1 in cochlear hair cells
3) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.06 Pain Relevance 0.10
We next examined which classes of DRG neurons express NMB-1-sensitive mechanically activated currents.
Gene_expression (express) of NMB-1 in neurons
4) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.17 Pain Relevance 0.19
The most efficient antagonist, termed NMB-1, was identified as an analogue of ?
Gene_expression (termed) of NMB-1 associated with antagonist
5) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.06 Pain Relevance 0.25
NMB-1 is a selective antagonist of slowly adapting mechanically activated currents in sensory neurons
Gene_expression (selective) of NMB-1 in sensory neurons associated with antagonist
6) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.15 Pain Relevance 0.30

General Comments

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