INT208617

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 1.57
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nmbr) cytoplasm (Nmbr) signal transducer activity (Nmbr)
Anatomy Link Frequency
neurons 8
sensory neuron 2
pore 1
nociceptors 1
Nmbr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 208 98.84 Very High Very High Very High
Mechanosensation 78 94.72 High High
Mechanotransduction 91 92.48 High High
qutenza 182 92.40 High High
Root ganglion neuron 13 91.96 High High
Calcium channel 26 85.76 High High
Pain 169 83.16 Quite High
low threshold mechanoreceptor 104 79.52 Quite High
action potential duration 13 78.72 Quite High
ASIC 39 74.92 Quite High
Disease Link Frequency Relevance Heat
Nociception 104 98.56 Very High Very High Very High
Rheumatoid Arthritis 260 91.88 High High
Ganglion Cysts 13 91.64 High High
Pain 169 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nearly all peripherin-positive neurons bound biotinylated NMB-1 and almost all NMB-1-positive cells showed peripherin immunoreactivity.
NMB-1 Binding (bound) of in neurons
1) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.08 Pain Relevance 0.11
To double label neurons for biotinylated NMB-1 binding and peripherin immunoreactivity, fixed cells were stained using a mouse anti-peripherin antibody (diluted 1?
NMB-1 Binding (binding) of in neurons
2) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0 Pain Relevance 0.06
We found that biotinylated NMB-1 selectively bound to peripherin-containing DRG neurons, most of which are nociceptors.
NMB-1 Binding (bound) of in nociceptors associated with nociceptor
3) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0 Pain Relevance 0.43
Thirdly, biotinylated NMB-1 bound to unstimulated peripherin-positive DRG neurons, with a pattern similar to the distribution of the SA currents.
NMB-1 Binding (bound) of in neurons
4) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.15 Pain Relevance 0.36
Peptide activity was strongly voltage-dependent suggesting that NMB-1 may be a pore-blocking compound, binding within the membrane's electric field.
NMB-1 Binding (binding) of in pore
5) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.06 Pain Relevance 0.10
NMB-1 binding was not observed in large diameter DRG neurons (Fig. 6d).
NMB-1 Binding (binding) of in neurons
6) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.09 Pain Relevance 0.03
We found that small diameter sensory neurons that express peripherin represented the major class of NMB-1 binding neurons (Fig 6a–c).
NMB-1 Binding (binding) of in neurons
7) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.08 Pain Relevance 0.12
NMB-1 selectively binds to a sub-population of DRG neurons
NMB-1 Binding (binds) of in neurons
8) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.06 Pain Relevance 0.27
We characterized the sensory neurons that bind NMB-1, using a biotinylated form of the peptide and a fluorescent streptavidin derivative, together with immunocytochemical markers for sensory neuron subsets.
NMB-1 Binding (bind) of in sensory neuron
9) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.05 Pain Relevance 0.25
To determine if NMB-1 could only bind or unbind open ion channels, we applied the toxin (1 µM) to neurons whilst they were stimulated at different frequencies, either every 12 sec or every 24 sec (slow channel inactivation precluded more frequent stimulation).
NMB-1 Binding (bind) of in neurons
10) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.23 Pain Relevance 0.03
Biotinylated NMB-1 retains activity and binds selectively to peripherin-positive nociceptive sensory neurons.
NMB-1 Binding (binds) of in sensory neurons associated with nociception
11) Confidence 0.19 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1885214 Disease Relevance 0.27 Pain Relevance 0.32
This conclusion is further supported by the histochemical observation that NMB-1 binds to a subset of unstimulated neurons (see below).
NMB-1 Binding (binds) of in neurons
12) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.25 Pain Relevance 0
Selective inhibition of SA currents by NMB-1 could arise from binding to open channels, but three findings strongly argue against this.
NMB-1 Binding (binding) of
13) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.24 Pain Relevance 0.75

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