INT208621

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.43
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Prph) plasma membrane (Nmbr) cytoplasm (Nmbr)
signal transducer activity (Nmbr)
Anatomy Link Frequency
sensory neurons 1
neurons 1
nociceptors 1
Prph (Rattus norvegicus)
Nmbr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 48 98.84 Very High Very High Very High
Mechanosensation 18 94.72 High High
Root ganglion neuron 3 91.96 High High
Mechanotransduction 21 91.68 High High
Calcium channel 6 87.84 High High
qutenza 42 84.20 Quite High
Pain 39 83.16 Quite High
ASIC 9 70.24 Quite High
low threshold mechanoreceptor 24 58.36 Quite High
action potential duration 3 57.56 Quite High
Disease Link Frequency Relevance Heat
Nociception 24 99.60 Very High Very High Very High
Ganglion Cysts 3 91.64 High High
Rheumatoid Arthritis 60 85.72 High High
Pain 39 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biotinylated NMB-1 retains activity and binds selectively to peripherin-positive nociceptive sensory neurons.
peripherin Binding (binds) of NMB-1 in sensory neurons associated with nociception
1) Confidence 0.05 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1885214 Disease Relevance 0.27 Pain Relevance 0.33
We found that biotinylated NMB-1 selectively bound to peripherin-containing DRG neurons, most of which are nociceptors.
peripherin-containing Binding (bound) of NMB-1 in nociceptors associated with nociceptor
2) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0 Pain Relevance 0.43
Thirdly, biotinylated NMB-1 bound to unstimulated peripherin-positive DRG neurons, with a pattern similar to the distribution of the SA currents.
peripherin Binding (bound) of NMB-1 in neurons
3) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.15 Pain Relevance 0.36

General Comments

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