INT208720

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.08
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dendrites 2
climbing fiber 1
synapses 1
pf (Mus musculus)
Pain Link Frequency Relevance Heat
depression 121 99.08 Very High Very High Very High
Glutamate receptor 48 95.92 Very High Very High Very High
Thalamus 2 79.20 Quite High
potassium channel 1 54.20 Quite High
Hippocampus 3 47.68 Quite Low
addiction 5 43.60 Quite Low
imagery 12 6.36 Low Low
Glutamate 7 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 29 99.16 Very High Very High Very High
Depression 121 99.08 Very High Very High Very High
Ataxia 2 93.24 High High
Adhesions 20 91.60 High High
Targeted Disruption 6 90.12 High High
Congenital Anomalies 4 49.12 Quite Low
Sprains And Strains 6 15.28 Low Low
Stress 3 9.92 Low Low
Increased Venous Pressure Under Development 20 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, no significant difference was found between the latter two experimental groups and the negative control (5.4┬▒0.65 SE) (one-way ANOVA, p<0.001; post hoc Holm-Sidack test, p>0.05), suggesting that in the granular layer, the ascending Golgi dendrites do not receive PF inputs under normal conditions.
Neg (not) Regulation (receive) of PF in dendrites
1) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0
We studied the robustness of our predictions by varying the PF activity level and found that the predictions of the model held for patterns with at least 750 and not more than 8000 synchronously active synapses (Figure S1).
Regulation (varying) of PF in synapses
2) Confidence 0.10 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.07 Pain Relevance 0.06
2 participates in the highly territorial competition between the two excitatory inputs to the PC; the climbing fiber (CF), which innervates the proximal dendritic compartment, and the PF, which is connected to spiny distal branchlets.
Regulation (participates) of PF in climbing fiber
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2666267 Disease Relevance 0.47 Pain Relevance 0.18
2 (T site) impairs LTD induction at PF-PC synapses and caused CF territory expansion, but had little effect on PF-PC synapse formation and elimination of surplus CFs at proximal dendrites of PCs [21].
Neg (little) Regulation (effect) of PF-PC in dendrites associated with depression
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.28 Pain Relevance 0.67
After twenty-eight weeks, the developed fetus is definitely present and would be affected for the worse by an abortion [48]."
Regulation (affected) of fetus associated with reprotox - general 1
5) Confidence 0.00 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC1892780 Disease Relevance 0.26 Pain Relevance 0

General Comments

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