INT20873

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.23
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTG1) nucleolus (MTG1) nucleus (MTG1)
Anatomy Link Frequency
plasma 1
NG108-15 1
brain 1
MTG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 14 99.22 Very High Very High Very High
Dopamine 7 98.32 Very High Very High Very High
Tetrahydrobiopterin 1 95.04 Very High Very High Very High
adenocard 1 94.04 High High
Serotonin 1 90.92 High High
cINOD 5 89.40 High High
agonist 11 88.72 High High
Substantia nigra 3 88.16 High High
Locus ceruleus 5 84.64 Quite High
Opioid 2 81.68 Quite High
Disease Link Frequency Relevance Heat
Dystonia 5 98.72 Very High Very High Very High
Vibrio Infection 9 98.64 Very High Very High Very High
Glioma 2 98.12 Very High Very High Very High
Neuroblastoma 2 97.94 Very High Very High Very High
Bordatella Infection 2 93.68 High High
INFLAMMATION 1 62.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of GTPase leads, in turn, to inactivation of GTP-stimulated adenylate cyclase activity.
Negative_regulation (inactivation) of GTP
1) Confidence 0.42 Published 1982 Journal J. Biol. Chem. Section Abstract Doc Link 6128341 Disease Relevance 0.17 Pain Relevance 0.67
In both, there are deficiencies in GTP cyclohydrolase I and low brain levels of dopamine (DA).
Negative_regulation (deficiencies) of GTP in brain associated with dopamine
2) Confidence 0.42 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.35 Pain Relevance 0.48
Treatment of NG108-15 neuroblastoma x glioma cells (24 h) with cholera toxin (0.1-10 micrograms/ml) resulted in a concentration-dependent reduction of the membrane levels of subunits of GTP-binding regulatory proteins (G proteins), as determined by quantitative immunoblot procedures.
Negative_regulation (reduction) of GTP in NG108-15 associated with neuroblastoma, vibrio infection and glioma
3) Confidence 0.41 Published 1990 Journal Eur. J. Biochem. Section Abstract Doc Link 2158884 Disease Relevance 0.55 Pain Relevance 0
These findings fit with biochemical models which propose that alpha 2- and opiate receptors have common actions through inhibiting adenylate cyclase through the inhibitory guanosine triphosphate (GTP) binding protein (Gi).
Negative_regulation (inhibiting) of GTP associated with opiate
4) Confidence 0.41 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2443865 Disease Relevance 0.09 Pain Relevance 0.85
Salicylate and piroxicam inhibited GTP gamma S binding to G alpha/beta gamma derived from solubilized plasma membranes reconstituted in phosphatidylcholine vesicles (bilayer structures) but had no effect when phosphatidylethanolamine (hexagonal phase II structure) was used for reconstitution.
Negative_regulation (inhibited) of GTP in plasma
5) Confidence 0.41 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 8117325 Disease Relevance 0.06 Pain Relevance 0.25
Compounds either stimulated or inhibited [35S]GTP gamma S binding to a membrane preparation containing either h5-HT1B or h5-HT1D receptors.
Negative_regulation (inhibited) of GTP
6) Confidence 0.41 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225275 Disease Relevance 0 Pain Relevance 0.08

General Comments

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