INT20873

Context Info Confidence 0.42 First Reported 1982 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 1.23 Pain Relevance 2.34

mitochondrion (MTG1) nucleolus (MTG1) nucleus (MTG1)

Anatomy Link Frequency plasma 1 NG108-15 1 brain 1 MTG1 (Homo sapiens)

Pain Link Frequency Relevance Heat opiate 14 99.22 Dopamine 7 98.32 Tetrahydrobiopterin 1 95.04 adenocard 1 94.04 Serotonin 1 90.92 cINOD 5 89.40 agonist 11 88.72 Substantia nigra 3 88.16 Locus ceruleus 5 84.64 Opioid 2 81.68

Disease Link Frequency Relevance Heat Dystonia 5 98.72 Vibrio Infection 9 98.64 Glioma 2 98.12 Neuroblastoma 2 97.94 Bordatella Infection 2 93.68 INFLAMMATION 1 62.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of GTPase leads, in turn, to inactivation of GTP-stimulated adenylate cyclase activity.

Negative_regulation (inactivation) of GTP

1) Confidence 0.42 Published 1982 Journal J. Biol. Chem. Section Abstract Doc Link 6128341 Disease Relevance 0.17 Pain Relevance 0.67

In both, there are deficiencies in GTP cyclohydrolase I and low brain levels of dopamine (DA).

Negative_regulation (deficiencies) of GTP in brain associated with dopamine

2) Confidence 0.42 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.35 Pain Relevance 0.48

Treatment of NG108-15 neuroblastoma x glioma cells (24 h) with cholera toxin (0.1-10 micrograms/ml) resulted in a concentration-dependent reduction of the membrane levels of subunits of GTP-binding regulatory proteins (G proteins), as determined by quantitative immunoblot procedures.

Negative_regulation (reduction) of GTP in NG108-15 associated with neuroblastoma, vibrio infection and glioma

3) Confidence 0.41 Published 1990 Journal Eur. J. Biochem. Section Abstract Doc Link 2158884 Disease Relevance 0.55 Pain Relevance 0

These findings fit with biochemical models which propose that alpha 2- and opiate receptors have common actions through inhibiting adenylate cyclase through the inhibitory guanosine triphosphate (GTP) binding protein (Gi).

Negative_regulation (inhibiting) of GTP associated with opiate

4) Confidence 0.41 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2443865 Disease Relevance 0.09 Pain Relevance 0.85

Salicylate and piroxicam inhibited GTP gamma S binding to G alpha/beta gamma derived from solubilized plasma membranes reconstituted in phosphatidylcholine vesicles (bilayer structures) but had no effect when phosphatidylethanolamine (hexagonal phase II structure) was used for reconstitution.

Negative_regulation (inhibited) of GTP in plasma

5) Confidence 0.41 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 8117325 Disease Relevance 0.06 Pain Relevance 0.25

Compounds either stimulated or inhibited [35S]GTP gamma S binding to a membrane preparation containing either h5-HT1B or h5-HT1D receptors.

Negative_regulation (inhibited) of GTP

6) Confidence 0.41 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225275 Disease Relevance 0 Pain Relevance 0.08

General Comments

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