INT208763

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH1) extracellular space (CSF2) small molecule metabolic process (TPH1)
extracellular region (CSF2) cellular nitrogen compound metabolic process (TPH1) response to stress (TPH1)
CSF2 (Homo sapiens)
TPH1 (Homo sapiens)
TPH1 - A779C (1)
Pain Link Frequency Relevance Heat
Serotonin 13 100.00 Very High Very High Very High
addiction 1 97.56 Very High Very High Very High
Nicotine 1 97.12 Very High Very High Very High
Dopamine 3 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
Triptan 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Raphe 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 36 99.56 Very High Very High Very High
Nicotine Addiction 1 97.56 Very High Very High Very High
Stress 5 97.36 Very High Very High Very High
Disease 3 77.44 Quite High
Mental Disorders 5 5.00 Very Low Very Low Very Low
Psychosis 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Weight Gain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TPH1 A779C A-genotype has been associated with lowered serotonin metabolite 5-HIAA levels in the CSF [17], and on the other hand the functions of TPH1 are related to stress response, which may be associated with susceptibility to schizophrenia [20].
CSF Binding (associated) of TPH1 (A779C) associated with stress, serotonin and schizophrenia
1) Confidence 0.07 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.65 Pain Relevance 0.19

General Comments

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