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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH1) small molecule metabolic process (TPH1) cellular nitrogen compound metabolic process (TPH1)
response to stress (TPH1)
TPH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 16 98.76 Very High Very High Very High
monoamine 2 98.00 Very High Very High Very High
Dopamine 3 72.20 Quite High
Raphe 1 72.16 Quite High
depression 30 68.08 Quite High
Potency 1 68.04 Quite High
antagonist 1 66.92 Quite High
antidepressant 5 64.08 Quite High
Hippocampus 1 60.40 Quite High
Catecholamine 1 58.80 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 36 99.60 Very High Very High Very High
Endometriosis (extended) 26 83.84 Quite High
Depression 38 82.24 Quite High
Cognitive Disorder 3 62.96 Quite High
Stress 5 51.68 Quite High
Mental Disorders 5 48.48 Quite Low
Cardiovascular Disease 1 17.28 Low Low
Pressure And Volume Under Development 1 10.24 Low Low
Disease 3 9.92 Low Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic variation of TPH1 gene has been associated with the risk of schizophrenia in two recently published studies [15,16].
Positive_regulation (variation) of TPH1 associated with schizophrenia
1) Confidence 0.50 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.33 Pain Relevance 0.43
Estradiol (E2) administration decreases the activity of monoamine oxidases (MAO-A and MAO-B), which are enzymes involved in 5-HT degradation; E2 administration also increases both isoforms of tryptophan hydroxylase (TPH), the rate-limiting enzyme of serotonin synthesis, resulting in an overall increase in 5-HT synthesis and availability.
Positive_regulation (increases) of TPH associated with serotonin and monoamine
2) Confidence 0.49 Published 2010 Journal BMC Med Section Body Doc Link PMC3003619 Disease Relevance 0.37 Pain Relevance 0.35

General Comments

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