INT208789

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
neurons 2
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 49 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
Neurotransmitter 2 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Central nervous system 2 90.84 High High
methadone 135 74.32 Quite High
Enkephalin 3 64.64 Quite High
Nerve growth factor 1 63.44 Quite High
Buprenorphine 88 50.00 Quite Low
withdrawal 25 46.80 Quite Low
Disease Link Frequency Relevance Heat
Opiate Addiction 27 46.80 Quite Low
Newborn Drug Withdrawal Syndrome 37 35.68 Quite Low
Overdose 7 5.00 Very Low Very Low Very Low
Recurrence 6 5.00 Very Low Very Low Very Low
Drug Dependence 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, after differentiation, strong TH expression was shown in the ReNcell VM neurons both by Western blot and immunocytochemical analysis (colabelling of TH and ?
Negative_regulation (shown) of Localization (colabelling) of TH in neurons associated with midbrain
1) Confidence 0.25 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1888696 Disease Relevance 0 Pain Relevance 0.22
In particular, there are consistent decreases in protein, DNA, RNA and neurotransmitter content (serotonin, dopamine, norepinephrine) [87, 145, 253, 301, 344], enzymatic protein levels (tyrosine hydroxylase, acetylcholine-esterase, choline acetyltransferase, ornithine decarboxylase) [87, 224, 327, 338, 342, 343], and receptor expression (?
Negative_regulation (decreases) of Localization (choline acetyltransferase) of tyrosine hydroxylase associated with dopamine, neurotransmitter and serotonin
2) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0 Pain Relevance 0.67

General Comments

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