INT208792

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.11
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
neurons 4
striatum 4
enteric nervous system 2
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 86 99.36 Very High Very High Very High
substance P 10 97.76 Very High Very High Very High
Substantia nigra 216 96.04 Very High Very High Very High
Central nervous system 3 81.56 Quite High
Dopamine 101 68.00 Quite High
Neurotransmitter 4 47.88 Quite Low
alcohol 1 39.00 Quite Low
Action potential 20 32.24 Quite Low
Intracerebroventricular 1 19.04 Low Low
imagery 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 29 99.82 Very High Very High Very High
Disease 195 98.60 Very High Very High Very High
Enteropathy 1 98.52 Very High Very High Very High
Diabetes Mellitus 45 98.04 Very High Very High Very High
Injury 3 73.48 Quite High
Toxicity 46 66.88 Quite High
Gastric Motility Disorder 27 54.96 Quite High
Apoptosis 10 26.00 Quite Low
Cancer 4 20.48 Low Low
Congenital Anomalies 7 11.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latter is also associated with loss of nNOS and TH expression but by contrast, presents with increased expression of SP [26], suggesting regional variations in the effects of diabetes on the enteric nervous system.
Negative_regulation (loss) of Gene_expression (expression) of TH in enteric nervous system associated with diabetes mellitus and substance p
1) Confidence 0.35 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.71 Pain Relevance 0.11
It has already been demonstrated that aberrant sprouting of fibres and downregulation of tyrosine hydroxylase expression occurs (Georgievska et al 2002; Rosenblad et al 2003) which could potentially limit functional recovery in the long term.
Negative_regulation (downregulation) of Gene_expression (expression) of tyrosine hydroxylase
2) Confidence 0.32 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.07 Pain Relevance 0.03
To see whether the observed reduction in TH expression was maintained, we analyzed tissues that had been exposed to AAV1/2-A53T ?
Negative_regulation (reduction) of Gene_expression (expression) of TH
3) Confidence 0.27 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0 Pain Relevance 0.03
In contrast, after differentiation, strong TH expression was shown in the ReNcell VM neurons both by Western blot and immunocytochemical analysis (colabelling of TH and ?
Negative_regulation (shown) of Gene_expression (expression) of TH in neurons associated with midbrain
4) Confidence 0.25 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1888696 Disease Relevance 0 Pain Relevance 0.19
There was a reduced number of nigral TH-immunoreactive neurons, as well as reduction in total neuronal (NeuN) number, and, within the striatum, a loss of TH-immunoreactive fibre density and the presence of ?
Negative_regulation (number) of Gene_expression (neurons) of TH-immunoreactive in striatum
5) Confidence 0.23 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.16 Pain Relevance 0.11
Expression of A53T alpha synuclein, but not GFP, reduces tyrosine hydroxylase expression in the striatum
Negative_regulation (reduces) of Gene_expression (expression) of tyrosine hydroxylase in striatum
6) Confidence 0.23 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.07 Pain Relevance 0.13
When we supplemented the culture medium with FGF-20, the number of tyrosine hydroxylase (TH)-expressing neurons increased fivefold, from 3% to 15% of the hESC-derived cells.
Negative_regulation (number) of Gene_expression (expressing) of tyrosine hydroxylase in neurons
7) Confidence 0.18 Published 2007 Journal Frontiers in Neuroanatomy Section Abstract Doc Link PMC2525922 Disease Relevance 0 Pain Relevance 0.21
To establish that changes in TH+ cells reflected cell death and not reduced expression of TH protein, additional cell counts were performed in parallel for NeuN-positive (NeuN+) cells in the SN as described above.


Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of TH associated with substantia nigra and death
8) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2824797 Disease Relevance 0.10 Pain Relevance 0.12

General Comments

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