INT208851

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.63
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppia) nucleus (Ppia)
Anatomy Link Frequency
cornea 1
Ppia (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 8 97.52 Very High Very High Very High
cytokine 2 72.52 Quite High
cerebral cortex 10 71.20 Quite High
member 8 12 67.08 Quite High
anesthesia 3 34.16 Quite Low
ketamine 2 30.08 Quite Low
imagery 2 20.76 Low Low
Inflammation 42 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 26 99.54 Very High Very High Very High
Keratitis 26 99.16 Very High Very High Very High
Corneal Neovascularization 4 98.56 Very High Very High Very High
Cv Unclassified Under Development 6 97.52 Very High Very High Very High
Aspergillus Infection 6 95.40 Very High Very High Very High
Candida Infection 6 94.40 High High
Infection 4 93.52 High High
Chemical Burns 10 92.64 High High
Middle Cerebral Artery Infarction 1 90.00 High High
Malignant Neoplastic Disease 16 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of 8 HKGs (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], lactate dehydrogenase A [LDHA], ribosomal protein L5 [RPL5], ubiquitin C [UBC], peptidylprolyl isomerase A [PPIA], TATA-box binding protein [TBP1], and hypoxanthine guanine phosphoribosyl transferase [HPRT1]) in the cornea were measured at various time points by microarray hybridization or qRT–PCR and the data analyzed using geNorm and NormFinder.


Spec (analyzed) Gene_expression (Expression) of PPIA in cornea
1) Confidence 0.47 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2893048 Disease Relevance 0.84 Pain Relevance 0
In this paper, we establish models of experimental corneal neovascularization (CorNV), fungal keratitis (FK) and corneal wound in mice and study the expression patterns of three traditional HKGs (ACTB, lactate dehydrogenase [LDHA], and GAPDH), five new HKGs (ubiquitin C [UBC] [14], peptidylprolyl isomerase A [PPIA] [15], TATA-box binding protein [TBP] [16], hypoxanthine guanine phosphoribosyl transferase [HPRT1] [17], and ribosomal protein L5 [RPL5] [18]).
Gene_expression (expression) of PPIA associated with corneal neovascularization, injury and keratitis
2) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2893048 Disease Relevance 0.40 Pain Relevance 0.04
The results have also shown that, the previously postulated housekeeping genes namely peptidyl-prolyl cis-trans isomerase A (PPIase), GAPDH, beta-actin are not constantly expressed in all the tissues.


Neg (not) Gene_expression (expressed) of peptidyl-prolyl cis-trans isomerase
3) Confidence 0.34 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.21 Pain Relevance 0.10
It has been shown, that the expression for example of Actb, Gapdh or CypA, commonly used control genes, varies considerably, depending on the model used and the time points analyzed.
Gene_expression (expression) of CypA
4) Confidence 0.27 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2430208 Disease Relevance 0.49 Pain Relevance 0.16
In addition, we report previously postulated housekeeping genes such as peptidyl-prolyl cis-trans isomerase A, glyceraldehyde-3-phosphate dehydrogenase and beta-actin, which are expressed in all the tissues, but with significant difference in their expression levels.
Gene_expression (expressed) of peptidyl-prolyl cis-trans isomerase
5) Confidence 0.27 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
Invariably expressed PPIA was used as a loading control.
Gene_expression (expressed) of PPIA
6) Confidence 0.23 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 0.46 Pain Relevance 0
RT-PCR with primers to invariantly expressed PPIA (5'-TCTGAGCACTGGAGAGAAAGG-3', 5'-GGAAAACATGGAACCCAAAGG-3') was used as a loading control.
Gene_expression (expressed) of PPIA
7) Confidence 0.15 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 0.23 Pain Relevance 0

General Comments

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