INT208874

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 0.98
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sv2b) transmembrane transporter activity (Sv2b) transmembrane transport (Sv2b)
Anatomy Link Frequency
cerebral cortex 4
neurons 2
spinal cord 1
brain 1
Sv2b (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 25 99.84 Very High Very High Very High
Glutamate 8 99.10 Very High Very High Very High
Neurotransmitter 17 97.00 Very High Very High Very High
Spinal cord 138 94.96 High High
Hippocampus 5 92.08 High High
cocaine 5 90.00 High High
Central nervous system 18 67.88 Quite High
Neuropeptide 10 65.28 Quite High
Inflammation 15 8.12 Low Low
tetrodotoxin 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 66 99.84 Very High Very High Very High
Targeted Disruption 18 98.96 Very High Very High Very High
Disease 23 86.48 High High
Paralysis 21 57.40 Quite High
Stress 5 34.16 Quite Low
Trismus 3 25.00 Low Low
Infection 12 15.48 Low Low
INFLAMMATION 15 8.12 Low Low
Obesity 50 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that SV2B expression is largely localized to excitatory terminals while SV2A is preferentially localized to inhibitory neurons in both cortical cultures and spinal cord slices; this differential distribution was more striking with cortical neurons.
Gene_expression (expression) of SV2B in spinal cord associated with spinal cord
1) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.12
To further investigate how TeNT is directed to specific populations of neurons, we examined the distribution of SV2A and SV2B in both preparations.
Spec (examined) Gene_expression (distribution) of SV2B in neurons
2) Confidence 0.46 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.11
SV2B is expressed in cerebral cortex, therefore further studies on the expression pattern of SV2B are needed to investigate the consistency with its function as a specific neurotransmitter transporter [65].
Gene_expression (expressed) of SV2B in cerebral cortex associated with neurotransmitter and cerebral cortex
3) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0.29
SV2B is expressed in cerebral cortex, therefore further studies on the expression pattern of SV2B are needed to investigate the consistency with its function as a specific neurotransmitter transporter [65].
Gene_expression (expression) of SV2B in cerebral cortex associated with neurotransmitter and cerebral cortex
4) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0.29
SV2B expression was observed to change during development; it is more widely expressed in the immature brain and is found in cells that have yet to establish synaptic contacts.
Gene_expression (expression) of SV2B in brain
5) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0.25
The current study reports that solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter) member 7, also known as vesicular glutamate transporters (Vglut1), and synaptic vesicle glycoprotein 2 b (SV2B) as well as gene model 748 were exclusively expressed in cerebral cortex.
Gene_expression (expressed) of SV2B in cerebral cortex associated with glutamate and cerebral cortex
6) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0.17
Toxin entry into knockout neurons was rescued by infecting with viruses that express SV2A or SV2B.
Gene_expression (express) of SV2B in neurons associated with targeted disruption
7) Confidence 0.42 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2991259 Disease Relevance 0.98 Pain Relevance 0.24
The current study reports that solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter) member 7, also known as vesicular glutamate transporters (Vglut1), and synaptic vesicle glycoprotein 2 b (SV2B) as well as gene model 748 were exclusively expressed in cerebral cortex.
Gene_expression (expressed) of glycoprotein 2 b in cerebral cortex associated with glutamate and cerebral cortex
8) Confidence 0.39 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0.17

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