INT208890

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.42
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Anatomy Link Frequency
monocytes 1
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 91 99.76 Very High Very High Very High
rheumatoid arthritis 76 99.12 Very High Very High Very High
Inflammatory response 14 97.76 Very High Very High Very High
member 8 6 96.24 Very High Very High Very High
tolerance 42 95.16 Very High Very High Very High
Inflammation 127 91.92 High High
Osteoarthritis 1 79.04 Quite High
Arthritis 64 61.52 Quite High
Central nervous system 24 44.64 Quite Low
agonist 8 44.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 27 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Rheumatoid Arthritis 76 99.12 Very High Very High Very High
INFLAMMATION 115 97.36 Very High Very High Very High
Bacterial Infection 4 87.68 High High
Osteoarthritis 1 79.04 Quite High
Repression 3 75.60 Quite High
Multiple Organ Failure 1 75.44 Quite High
Arthritis 64 62.56 Quite High
Disease 70 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IRAK-M is a catalytically inactive member of the IRAK kinase family that prevents formation of IRAK-1–TRAF6 complexes downstream of TLR4 (15, 16).
Gene_expression (complexes) of IRAK
1) Confidence 0.65 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.17 Pain Relevance 0.38
B and subsequent production of proinflammatory cytokines while also inhibiting IRAK1 resulting in an increase in IFN-?
Gene_expression (resulting) of IRAK1 associated with cytokine
2) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.05 Pain Relevance 0.14
B and subsequent production of proinflammatory cytokines while also inhibiting IRAK1 resulting in an increase in IFN-?
Gene_expression (inhibiting) of IRAK1 associated with cytokine
3) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.06 Pain Relevance 0.14
Interestingly, TRAF6, and IRAK-1, two targets of miR-146a [107] were produced at similar levels in RA and control monocytes, despite the finding of increased miR-146 expression by RA monocytes.
Gene_expression (produced) of IRAK-1 in monocytes associated with rheumatoid arthritis
4) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.18 Pain Relevance 0.61
This event allows activation of the IL-1R-associated kinase (IRAK)/tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway leading to nuclear translocation of the nuclear factor kappa beta (NF-?
Gene_expression (necrosis) of IRAK associated with necrosis and cancer
5) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.20 Pain Relevance 0
Several different components are involved in TLR signaling, such as IL-1 receptor-associated kinases (IRAK), leading to nuclear translocation of nuclear factor-?
Gene_expression (signaling) of IRAK
6) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.77 Pain Relevance 0.32
Previous studies have presented interleukin-12 receptor beta 2 [18] and interleukin-1 receptor-associated kinase [17] as ubiquitously expressed genes.
Gene_expression (expressed) of interleukin-1 receptor-associated kinase
7) Confidence 0.13 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0.27

General Comments

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