INT208918

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-5) nucleus (Nkx2-5) DNA binding (Nkx2-5)
transcription factor binding (Nkx2-5) cytoplasm (Nkx2-5)
Anatomy Link Frequency
urinary bladders 2
mesoderm 2
Nkx2-5 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 22 93.52 High High
Inflammation 28 50.00 Quite Low
Serotonin 1 11.92 Low Low
Action potential 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
interstitial cystitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 98.60 Very High Very High Very High
Toxicity 2 97.36 Very High Very High Very High
Disease 15 90.48 High High
Muscular Dystrophy 1 76.00 Quite High
Hypopituitarism 11 61.04 Quite High
Teratoma 4 56.84 Quite High
INFLAMMATION 34 50.00 Quite Low
Myotonic Dystrophy 8 50.00 Quite Low
Bladder Disease 3 49.84 Quite Low
Myocardial Infarction 13 19.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior to initiation of Nkx2-5 expression, coinciding with cardiac progenitor induction, the detection of Brachyury transcripts (day 4) indicated the formation of nascent mesoderm.
Positive_regulation (initiation) of Gene_expression (expression) of Nkx2-5 in mesoderm
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.06 Pain Relevance 0
Because of the high level of expression of both NKx-2.5 and NF-kappaB in the bladders pre-treated with saline, in an additional group, urinary bladders were removed without insertion of the catheter or fluid instillation.
Positive_regulation (level) of Gene_expression (expression) of NKx-2.5 in urinary bladders
2) Confidence 0.20 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
Levels of NKX2-5 increased in cardiac tissue in a reversible transgenic mouse model for RNA toxicity [43].
Positive_regulation (increased) of Gene_expression (Levels) of NKX2-5 associated with targeted disruption and toxicity
3) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.42 Pain Relevance 0

General Comments

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