INT208925

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-5) nucleus (Nkx2-5) DNA binding (Nkx2-5)
transcription factor binding (Nkx2-5) cytoplasm (Nkx2-5)
Anatomy Link Frequency
bladder 2
Nkx2-5 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 44 99.98 Very High Very High Very High
Inflammatory response 8 64.64 Quite High
Inflammation 56 50.00 Quite Low
Serotonin 2 27.80 Quite Low
antagonist 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
interstitial cystitis 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Disease 6 73.08 Quite High
INFLAMMATION 66 64.64 Quite High
Cancer 8 20.24 Low Low
Cystitis 30 14.80 Low Low
Shock 4 7.88 Low Low
Overactive Bladder 14 5.00 Very Low Very Low Very Low
Edema 12 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravesical instillation of SP stimulates NF-kappaB and Nkx-2.5 translocation in the bladder mucosa
Positive_regulation (stimulates) of Localization (translocation) of Nkx-2.5 in bladder associated with substance p
1) Confidence 0.21 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
Next, we used EMSA to confirm that selected TREs (NF-kappaB and NKx-2.5) are indeed part of the molecular network downstream of NK1R activation.
Positive_regulation (activation) of Localization (selected) of NKx-2.5
2) Confidence 0.18 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.14 Pain Relevance 0.06

General Comments

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