INT208930

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pard3) cytoskeleton (Pard3) cell cycle (Pard3)
cell division (Pard3) protein complex (Pard3) cytoplasm (Pard3)
Anatomy Link Frequency
neurons 2
bladder 1
Pard3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 52 100.00 Very High Very High Very High
substance P 32 67.76 Quite High
Pain 14 50.08 Quite High
antagonist 5 48.68 Quite Low
nociceptor 32 47.52 Quite Low
interstitial cystitis 2 43.20 Quite Low
qutenza 28 35.36 Quite Low
nud 1 35.28 Quite Low
bradykinin 9 31.00 Quite Low
agonist 28 19.44 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 59 100.00 Very High Very High Very High
Cancer 4 87.04 High High
Overactive Bladder 7 52.32 Quite High
Pain 15 50.08 Quite High
Nociception 42 50.00 Quite Low
Interstitial Cystitis 2 43.20 Quite Low
Urinary Tract Disease 1 38.84 Quite Low
Dyspepsia 1 35.28 Quite Low
Cystitis 15 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this more conclusively it would be desirable to activate PAR3 alone, but specific activation of PAR3 in neurons coexpressing PAR1 and PAR4 is not possible because PAR3 peptides also activate PAR1 and PAR4 [45,46].
Positive_regulation (activation) of PAR3 in neurons
1) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
To test this more conclusively it would be desirable to activate PAR3 alone, but specific activation of PAR3 in neurons coexpressing PAR1 and PAR4 is not possible because PAR3 peptides also activate PAR1 and PAR4 [45,46].
Positive_regulation (activate) of PAR3 in neurons
2) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
In the presence of NK1R, Nkx2-5 _01 was significantly correlated with 36 transcripts which included several candidates for mediating bladder development (FGF) and inflammation (PAR-3, IL-1R, IL-6, ?
Positive_regulation (mediating) of PAR-3 in bladder associated with inflammation
3) Confidence 0.08 Published 2007 Journal BMC Urol Section Abstract Doc Link PMC1888709 Disease Relevance 0.49 Pain Relevance 0.27

General Comments

This test has worked.

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