INT208932

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.49
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
neurons 2
DRG 1
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 151 99.80 Very High Very High Very High
Serotonin 1 98.84 Very High Very High Very High
nociceptor 103 78.84 Quite High
c fibre 85 77.84 Quite High
Peripheral nervous system 6 75.56 Quite High
Inflammation 38 73.52 Quite High
dorsal root ganglion 24 70.80 Quite High
hyperexcitability 5 57.36 Quite High
addiction 10 51.36 Quite High
Spinal cord 27 39.60 Quite Low
Disease Link Frequency Relevance Heat
Cancer 4 99.42 Very High Very High Very High
Shock 2 93.24 High High
Targeted Disruption 76 92.76 High High
Adhesions 1 87.50 High High
Apoptosis 43 86.20 High High
Ganglion Cysts 354 85.32 High High
INFLAMMATION 43 73.52 Quite High
Death 39 64.36 Quite High
Nociception 14 58.80 Quite High
Neurodegenerative Disease 2 6.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, ret transcript levels are unchanged, whereas trkA mRNA levels increase by 37%.
Neg (unchanged) Regulation (unchanged) of ret transcript
1) Confidence 0.49 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.30 Pain Relevance 0.16
Their generation seems independent of ret and NGF signalling.
Neg (independent) Spec (seems) Regulation (independent) of ret associated with nerve growth factor
2) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.31
Coexpression of ret with cholinergic properties in chick sympathetic neurons has suggested the involvement of ret signalling in the development of this neuronal subset.
Regulation (involvement) of ret in neurons
3) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.05 Pain Relevance 0
During the third week of embryonic development, an increasing number of small neurons in DRG initiates ret expression, while expression in sympathetic ganglia is restricted to a subset of neurons thus distinguishing a “progressive increase” from a “progressive restriction” of gene expression to neuron subpopulations (arrow NGF requirement for the increase in the ret-positive population in DRG)Fig. 5Cholineric differentiation of sympathetic neurons during mouse embryogenesis.
Regulation (population) of ret-positive in DRG associated with nerve growth factor
4) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.09 Pain Relevance 0.08
The effect of ret mutation becomes apparent when the initially widespread expression of the cholinergic markers becomes restricted to a small subset of cells during the third week of embryonic development.
Regulation (effect) of ret
5) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0
Indeed, after forced Runx1 expression, we observed a selective up-regulation of RET, IB4-binding, and P2X3 in differentiated bTUB+ neurons, as well as a decrease of RT97 and CGRP expression in the transplants.
Regulation (regulation) of RET in neurons
6) Confidence 0.16 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.31 Pain Relevance 0.31
Overall NK1R-dependent genes were classified following the biological processes with which they are involved (GO anthology): apoptosis (GZMA, TNFRSF1B, TNFRSF1A, TRAF3, NOS2A, and BID); cell adhesion/hyaluronic acid binding (CD44 and AGC1); cell cycle (CCND2 and CCNG1); cell-cell signaling (FGF11 and GJA7); cytokinesis (CDC42 and KIF1B); development (FMR2); extracellular transporters & carriers (APOE); G-protein coupled receptors (GNA13 and PTGIR); growth factors (MXD1); heat shock proteins (PRNP, HSPH1, and HSPD1); immune response (BST-1, CTSW, and IL1R1); interferons (INFGR1) intracellular kinases (WBP6); intracellular transducers (MAP3K7); kinase activators & inhibitors (YWHAH); membrane channels (KCNAB1, KCNJ12, KCNQ1, and SLC30A4); nucleotide metabolism (PCSK1); oncogenes & tumor suppressors (BRCA1, MAP3K8, RET, VIL2, FLI1, MET, NF2, and VEGFR1); receptor mediated endocytosis (DAB2); receptor tyrosine kinase (EPHA2); regulation of transcription (NEUROD6); serotonin biosynthesis (YTPH1); symporters & antiporters (SLC16A1 and SLC1A1); transcription activators & repressors (FOXA1, HSF1, IER2, and NR1H2); and synaptic transmission (GRID1).


Regulation (regulation) of RET associated with cancer, shock, apoptosis, serotonin and adhesions
7) Confidence 0.04 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.73 Pain Relevance 0.11

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