INT208936

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tac1, Tacr1) signal transduction (Tacr1) extracellular space (Tac1)
extracellular region (Tac1) cytoplasm (Tacr1) signal transducer activity (Tacr1)
Anatomy Link Frequency
urinary bladder 1
Tac1 (Mus musculus)
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 22 100.00 Very High Very High Very High
Inflammation 28 84.48 Quite High
Pain 2 32.48 Quite Low
antagonist 5 31.08 Quite Low
interstitial cystitis 2 25.60 Quite Low
nud 1 25.00 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 91.48 High High
INFLAMMATION 33 84.48 Quite High
Overactive Bladder 7 34.72 Quite Low
Pain 3 32.48 Quite Low
Interstitial Cystitis 2 25.60 Quite Low
Urinary Tract Disease 1 25.00 Low Low
Dyspepsia 1 25.00 Low Low
Cystitis 15 5.00 Very Low Very Low Very Low
Edema 6 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophoretic mobility shift assays confirmed that, in the mouse urinary bladder, activation of NK1R by substance P (SP) induces both NKx-2.5 and NF-kappaB translocations.


substance P Positive_regulation (activation) of NK1R in urinary bladder associated with substance p
1) Confidence 0.13 Published 2007 Journal BMC Urol Section Abstract Doc Link PMC1888709 Disease Relevance 0.39 Pain Relevance 0.25

General Comments

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