INT208979

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Itpr3, Trpc3) nucleoplasm (Itpr3) endoplasmic reticulum (Itpr3)
nucleolus (Itpr3) nucleus (Itpr3) cytoplasm (Itpr3)
Anatomy Link Frequency
pore 1
Itpr3 (Rattus norvegicus)
Trpc3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 12 86.24 High High
Pain 48 50.00 Quite Low
qutenza 54 5.00 Very Low Very Low Very Low
antagonist 44 5.00 Very Low Very Low Very Low
Endep 20 5.00 Very Low Very Low Very Low
Dorsal horn neuron 16 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
IPN 10 5.00 Very Low Very Low Very Low
Analgesic 10 5.00 Very Low Very Low Very Low
wide dynamic range 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 79.96 Quite High
Death 4 78.48 Quite High
Pain 46 50.00 Quite Low
Nociception 16 5.00 Very Low Very Low Very Low
Inflammatory Pain 10 5.00 Very Low Very Low Very Low
Psychosis 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Cancer Pain 4 5.00 Very Low Very Low Very Low
Neuralgia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The former is known to block IP3RER binding to TRP3PM by direct competition, whereas, cognate domain from myosin light chain kinase, as well as calmidazolium, inhibit the interaction indirectly, due to prevention of Ca2+ loading of calmodulin.
IP3RER Binding (binding) of TRP3PM
1) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0.17 Pain Relevance 0.04
Indeed, one or two specific domains of IP3R can interact with cognate sites of TRP3PM and contribute to opening of the pore.
IP3R Binding (interact) of TRP3PM in pore
2) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

This test has worked.

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