INT20899

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.24
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (GNAI1) GTPase activity (GNAI1) cytoplasm (GNAI1)
signal transducer activity (GNAI1) signal transduction (GNAI1) nucleus (GNAI1)
Anatomy Link Frequency
myometrium 1
hepatocyte 1
lens 1
locus coeruleus 1
upper 1
GNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
pruritus 5 99.96 Very High Very High Very High
opiate 16 99.22 Very High Very High Very High
Morphine 27 99.12 Very High Very High Very High
Opioid 64 98.92 Very High Very High Very High
adenocard 8 97.76 Very High Very High Very High
agonist 22 97.60 Very High Very High Very High
Locus ceruleus 11 96.96 Very High Very High Very High
Migraine 10 96.28 Very High Very High Very High
analgesia 106 96.16 Very High Very High Very High
headache 5 95.00 High High
Disease Link Frequency Relevance Heat
Ulcers 13 99.96 Very High Very High Very High
Pruritus 5 99.96 Very High Very High Very High
Bordatella Infection 14 99.84 Very High Very High Very High
Vomiting 18 99.76 Very High Very High Very High
Overactive Bladder 2 99.04 Very High Very High Very High
Headache 11 96.28 Very High Very High Very High
Hemorrhage 12 94.20 High High
Cluster Headache 6 90.92 High High
Migraine With Aura 2 90.08 High High
Migraine Without Aura 2 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduced activity of Gi proteins seems to be unrelated to a reduction of protein levels since only a slight reduction (about 20-30%) of the Gi3alpha subunit was observed.
Negative_regulation (reduction) of Gi
1) Confidence 0.57 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669173 Disease Relevance 0.07 Pain Relevance 0
The reduced activity of Gi proteins seems not to be related to a reduction of protein levels since no significant reduction of the Gialpha subunits was observed.
Neg (no) Negative_regulation (reduction) of Gi
2) Confidence 0.42 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11298662 Disease Relevance 0.81 Pain Relevance 0.96
The reduced activity of Gi proteins seems to be unrelated to a reduction of protein levels since only a slight reduction (about 20-30%) of the Gi3alpha subunit was observed.
Negative_regulation (reduced) of Gi
3) Confidence 0.41 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669173 Disease Relevance 0.07 Pain Relevance 0
These findings fit with biochemical models which propose that alpha 2- and opiate receptors have common actions through inhibiting adenylate cyclase through the inhibitory guanosine triphosphate (GTP) binding protein (Gi).
Negative_regulation (inhibiting) of Gi associated with opiate
4) Confidence 0.41 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2443865 Disease Relevance 0.10 Pain Relevance 0.85
As would be predicted by this model, pretreatment with pertussis toxin, an inactivator of Gi, blocks the hyperpolarizing effects of alpha 2- and opiate agonists in the locus coeruleus.
Negative_regulation (inactivator) of Gi in locus coeruleus associated with bordatella infection, locus ceruleus, agonist and opiate
5) Confidence 0.41 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2443865 Disease Relevance 0.10 Pain Relevance 0.84
The lens protein sulfhydryl content is an indicator of protein oxidation and was significantly reduced in G-II compared to G-I and G-III.
Negative_regulation (reduced) of G-I in lens
6) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0 Pain Relevance 0
The reduced activity of Gi proteins seems not to be related to a reduction of protein levels since no significant reduction of the Gialpha subunits was observed.
Negative_regulation (reduced) of Gi
7) Confidence 0.41 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11298662 Disease Relevance 0.85 Pain Relevance 0.98
These results indicate the presence of alpha 2-adrenergic receptors in the human myometrium at the end of pregnancy that are functionally linked to inhibition of adenylate cyclase activity via the Gi protein.
Negative_regulation (inhibition) of Gi protein in myometrium
8) Confidence 0.06 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2159482 Disease Relevance 0.21 Pain Relevance 0.22
Similar to all other opioids, morphine can also cause nausea, vomiting, pruritus, decrease GI function, and possibly urinary retention.
Negative_regulation (decrease) of GI associated with vomiting, pruritus, overactive bladder, opioid and morphine
9) Confidence 0.06 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004641 Disease Relevance 1.07 Pain Relevance 1.85
Lumiracoxib showed, in the total group, a 3- to 4-fold reduction in upper GI ulcer complications (POBs) compared both comparators combined (RR: 0.34, CI: 0.22–0.52) and either naproxen or ibuprofen (Table 2).
Negative_regulation (reduction) of GI in upper associated with ulcers
10) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504080 Disease Relevance 0.71 Pain Relevance 0.21
When its overriding action on Gi is blocked by pertussis toxin pretreatment, the human receptor also enhances cAMP accumulation.
Negative_regulation (blocked) of Gi associated with bordatella infection
11) Confidence 0.03 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8282007 Disease Relevance 0.19 Pain Relevance 0.16
Further studies involving specific inhibition of Gi3 proteins will be needed to clarify this issue in the hepatocyte model.
Negative_regulation (inhibition) of Gi3 in hepatocyte
12) Confidence 0.02 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.06 Pain Relevance 0

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