INT208990

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.07
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
pore 1
CALM1 (Homo sapiens)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 66 98.32 Very High Very High Very High
qutenza 81 97.48 Very High Very High Very High
Endep 30 88.80 High High
antidepressant 6 86.96 High High
carbamazepine 6 79.76 Quite High
backache 3 73.68 Quite High
Pain 72 50.00 Quite Low
TRP channel 18 16.80 Low Low
Dorsal horn neuron 24 5.00 Very Low Very Low Very Low
agonist 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 3 74.32 Quite High
Pain 69 50.00 Quite Low
Nociception 24 5.00 Very Low Very Low Very Low
Inflammatory Pain 15 5.00 Very Low Very Low Very Low
Psychosis 9 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Cancer Pain 6 5.00 Very Low Very Low Very Low
Neuralgia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these experiments we hypothesized that maybe a calmodulin-like motif of TRPV1 is recognized extracellularly, therefore, a calmodulin antagonist with poor membrane permeability can exert inhibition without entering the cell.
calmodulin Binding (recognized) of TRPV1 associated with antagonist
1) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0 Pain Relevance 0.46
This particular domain of the pore loop may also serve as a cation filter and anti-calmodulin compounds can bind after Ca2+ binds first to this TRPV1 structure (Fig. 10), thereby preventing pore opening [44], [45].
calmodulin Binding (bind) of TRPV1 in pore
2) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0 Pain Relevance 0.07
Experiments with peptides suggested that camstatin and other anti-calmodulin agents indeed recognize an extracellular domain of TRPV1.
calmodulin Binding (recognize) of TRPV1
3) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0.07 Pain Relevance 0.75

General Comments

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