INT208991

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.34
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
brain 1
CALM1 (Homo sapiens)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 9 98.32 Very High Very High Very High
Spinal cord 25 97.84 Very High Very High Very High
Calcium channel 2 97.84 Very High Very High Very High
long-term potentiation 58 97.08 Very High Very High Very High
Neurotransmitter 13 95.96 Very High Very High Very High
antagonist 96 94.32 High High
nMDA receptor 42 94.00 High High
nMDA receptor antagonist 1 88.68 High High
Kinase C 16 82.64 Quite High
Central nervous system 16 79.64 Quite High
Disease Link Frequency Relevance Heat
Li-fraumeni Syndrome 24 83.32 Quite High
Neuropathic Pain 13 73.08 Quite High
Hyperalgesia 23 72.52 Quite High
Channelopathies 24 71.60 Quite High
Hypertension 18 68.36 Quite High
Diabetes Mellitus 28 67.80 Quite High
Erectile Dysfunction 74 60.68 Quite High
Disease 19 56.64 Quite High
Stress 4 55.68 Quite High
Inflammatory Pain 21 50.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calmodulin, due to interaction with Ca2+, undergoes a robust conformational change and exposes hidden hydrophobic docking site for trifluoperazine and other conventional calmodulin antagonists [18], [19], [46].
Calmodulin Binding (interaction) of Ca2 associated with antagonist
1) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0 Pain Relevance 0.08
Dose-dependent interaction of Ca2+ with calmodulin elicits a robust conformational change that exposes hidden hydrophobic domains required for subsequent effects on down-stream protein targets [18], [19].
calmodulin Binding (interaction) of Ca2
2) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0 Pain Relevance 0
Ca2+- calmodulin complex, formed upon entry of Ca2+ to the cytosol resulting in elevation of intracellular free calcium [Ca2+]i can turn on/off different enzymes and ion channels.
calmodulin Binding (complex) of Ca2
3) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0 Pain Relevance 0
Ca2+- calmodulin complex, formed upon entry of Ca2+ to the cytosol resulting in elevation of intracellular free calcium [Ca2+]i can turn on/off different enzymes and ion channels.
calmodulin Binding (complex) of Ca2
4) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0 Pain Relevance 0
A rise in [Ca2+]i may lead to Ca2+ binding to calmodulin, which in turn activates Ca2+-calmodulin dependent kinase II (CaMKII).
calmodulin Binding (binding) of Ca2
5) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.66 Pain Relevance 1.26
For example, it is known that Ca2+ binds to a constitutively associated calmodulin (CaM), which then interacts with other sites on the channel to induce CDI (Lee et al., 1999, 2003; Peterson et al., 1999; Zühlke et al., 1999; Erickson et al., 2001, 2003; Pitt et al., 2001; Mori et al., 2004; Dick et al., 2008; Tadross et al., 2008).
calmodulin Binding (associated) of Ca2
6) Confidence 0.00 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.07 Pain Relevance 0
For example, it is known that Ca2+ binds to a constitutively associated calmodulin (CaM), which then interacts with other sites on the channel to induce CDI (Lee et al., 1999, 2003; Peterson et al., 1999; Zühlke et al., 1999; Erickson et al., 2001, 2003; Pitt et al., 2001; Mori et al., 2004; Dick et al., 2008; Tadross et al., 2008).
calmodulin Binding (interacts) of Ca2
7) Confidence 0.00 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.07 Pain Relevance 0
For example, it is known that Ca2+ binds to a constitutively associated calmodulin (CaM), which then interacts with other sites on the channel to induce CDI (Lee et al., 1999, 2003; Peterson et al., 1999; Zühlke et al., 1999; Erickson et al., 2001, 2003; Pitt et al., 2001; Mori et al., 2004; Dick et al., 2008; Tadross et al., 2008).
calmodulin Binding (binds) of Ca2
8) Confidence 0.00 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.07 Pain Relevance 0
The increase of intracellular Ca2+ concentration results in calcium binding to calmodulin and activation of myosin light chain kinase [80].
calmodulin Binding (binding) of Ca2
9) Confidence 0.00 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 0.47 Pain Relevance 0.05
, which is activated by Ca2+ complexed with calmodulin and has a wide but uneven distribution in the mammalian brain, resembling in extent that of a major neurotransmitter (Bredt et al., 1991a; Vincent & Kimura, 1992).
calmodulin Binding (complexed) of Ca2 in brain associated with neurotransmitter
10) Confidence 0.00 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.16

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