INT209018

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 7.12
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc11a1) plasma membrane (Slc11a1) lysosome (Slc11a1)
Anatomy Link Frequency
urine 2
immune cells 1
bladder 1
Slc11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 503 99.48 Very High Very High Very High
Inflammation 353 98.32 Very High Very High Very High
Inflammatory stimuli 47 98.32 Very High Very High Very High
chemokine 140 90.32 High High
headache 8 88.32 High High
Inflammatory response 49 84.64 Quite High
pruritus 7 83.28 Quite High
Pain 7 78.64 Quite High
anesthesia 1 44.80 Quite Low
cva 3 8.08 Low Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 60 99.72 Very High Very High Very High
Overactive Bladder 55 99.60 Very High Very High Very High
INFLAMMATION 449 98.32 Very High Very High Very High
Infection 121 98.16 Very High Very High Very High
Salmonella Infection 9 97.84 Very High Very High Very High
Cancer 110 97.60 Very High Very High Very High
Bladder Cancer 52 97.08 Very High Very High Very High
Cystitis 28 94.80 High High
Myalgia 7 92.48 High High
Sprains And Strains 34 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It will be interesting to determine whether the discovered molecules could be a target for increased BCG efficacy or whether the molecules themselves have any anti-tumor activity.
Positive_regulation (increased) of BCG associated with cancer
1) Confidence 0.55 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.32 Pain Relevance 0
These efforts have revealed a critical role for the Slc11a1 gene (formally Nramp1) in early innate resistance to Salmonella infection [17].
Positive_regulation (role) of Slc11a1 associated with salmonella infection
2) Confidence 0.45 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1925087 Disease Relevance 0.85 Pain Relevance 0
However, our CHIP/Q-PCR results did not demonstrate a significant increase in IL-6 gene following acute and chronic BCG.
Positive_regulation (increase) of BCG
3) Confidence 0.19 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.56 Pain Relevance 0.41
These findings suggest that the therapeutic effects of BCG are due in part to the rapid accumulation of antigen presenting, and activated immune cells that are responsible for the production of a multiphasic immune response as demonstrated by the presence of TH1 (IFN-?
Positive_regulation (effects) of BCG in immune cells
4) Confidence 0.14 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.31 Pain Relevance 0.40
However, IL-17 was induced primarily in response to BCG (Figure 9).
Positive_regulation (response) of BCG
5) Confidence 0.14 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.41 Pain Relevance 0.74
Furthermore, PMNs isolated from the urine of BCG-treated patients were a major source of IL-8, growth-related oncogene-alpha, MIP-1?
Positive_regulation (urine) of BCG in urine
6) Confidence 0.14 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.50 Pain Relevance 0.13
Interestingly, the area of edema formation in response to BCG was biphasic, appearing as early as twenty four hours after BCG instillation and declining at fourteen days despite weekly instillations with BCG (Figure 5).
Positive_regulation (response) of BCG associated with pressure and volume under development
7) Confidence 0.14 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 1.37 Pain Relevance 0.37
In the present study, cytokine levels in the urine were elevated as early as 1 day after BCG instillation.
Positive_regulation (elevated) of BCG in urine associated with cytokine
8) Confidence 0.13 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.14 Pain Relevance 0.44
In order to determine the differences in bladder mucosa and detrusor gene regulation in response to BCG in comparison to those elicited by other inflammatory stimuli (LPS and TNF-?)
Positive_regulation (response) of BCG in bladder associated with overactive bladder and inflammatory stimuli
9) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.94 Pain Relevance 0.32
Interestingly, the present work confirms our recent findings [25] that BCG also up-regulates genes encoding several small GTPases, such as LRG47 [25] that are responsible for an organism's defense to intracellular pathogens.
Positive_regulation (regulates) of BCG
10) Confidence 0.09 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.06 Pain Relevance 0
BCG-MVA85A induced significantly stronger cellular immune responses to antigen 85 protein and antigen 85A SPP than BCG-BCG vaccination
Positive_regulation (vaccination) of BCG
11) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.34 Pain Relevance 0.21
BCG-MVA85A induced significantly stronger cellular immune responses to antigen 85 protein and antigen 85A SPP than BCG-BCG vaccination
Positive_regulation (responses) of BCG
12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.34 Pain Relevance 0.21
In BCG-BCG subjects, the response to SPP increased at 1 week post-vaccination (median 236 SFC/106 PBMC) compared with screening (median 102 SFC/106 PBMC).
Positive_regulation (increased) of BCG
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0 Pain Relevance 0
BCG-MVA85A induced significantly stronger cellular immune responses to antigen 85 protein and antigen 85A SPP than BCG-BCG vaccination
Positive_regulation (vaccination) of BCG
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.32 Pain Relevance 0.20
BCG-MVA85A induced significantly stronger cellular immune responses to antigen 85 protein and antigen 85A SPP than BCG-BCG vaccination
Positive_regulation (than) of BCG
15) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.33 Pain Relevance 0.20
BCG-MVA85A induced significantly stronger cellular immune responses to antigen 85 protein and antigen 85A SPP than BCG-BCG vaccination
Positive_regulation (responses) of BCG
16) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.33 Pain Relevance 0.20
In BCG-MVA85A subjects, the response to SPP increased markedly at 1 week post-vaccination (median 2147 SFC/106 PBMC), compared with values at screening (median 13 SFC/106 PBMC).
Positive_regulation (increased) of BCG
17) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0 Pain Relevance 0

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