INT209019

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 4.33
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc11a1) plasma membrane (Slc11a1) lysosome (Slc11a1)
Anatomy Link Frequency
bladder 4
plug 2
vesicles 2
urinary bladder 1
Slc11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 399 100.00 Very High Very High Very High
Inflammation 356 99.56 Very High Very High Very High
chemokine 99 98.24 Very High Very High Very High
Inflammatory stimuli 42 92.88 High High
Inflammatory response 44 68.84 Quite High
ketamine 2 67.52 Quite High
anesthesia 2 65.36 Quite High
Eae 7 61.68 Quite High
imagery 14 50.76 Quite High
interstitial cystitis 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 442 99.56 Very High Very High Very High
Cystitis 23 96.04 Very High Very High Very High
Overactive Bladder 138 95.28 Very High Very High Very High
Cancer 278 94.00 High High
Bladder Cancer 117 94.00 High High
Hypersensitivity 31 92.88 High High
Sprains And Strains 17 90.24 High High
Injury 21 87.80 High High
Stress Incontinence 2 72.68 Quite High
Granuloma 46 50.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice were randomly assigned to either a control group (receiving PBS) or two treatment groups (receiving BCG or rBCG-S1PT).
Localization (receiving) of rBCG
1) Confidence 0.33 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.60 Pain Relevance 0.13
Mice were randomly assigned to either a control group (receiving PBS) or two treatment groups (receiving BCG or rBCG-S1PT).
Localization (receiving) of BCG
2) Confidence 0.29 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.60 Pain Relevance 0.13
Others have found that BCG also releases IL-10 from the mouse bladder [37].
Localization (releases) of BCG in bladder
3) Confidence 0.25 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.59 Pain Relevance 0.37
BCG-induced cytokine release
Localization (release) of BCG associated with cytokine
4) Confidence 0.22 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.45 Pain Relevance 0.54
Among the cytokines released by BCG, attention has been paid to IL-6 because its urinary levels are correlated with symptom scores in cystitis [50,51] and are reduced by BCG therapy in bladder cancer [52].
Localization (released) of BCG in bladder associated with bladder cancer, cystitis and cytokine
5) Confidence 0.20 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.43 Pain Relevance 0.49
In this first manuscript, we propose to determine whether the intact mouse urinary bladder takes up BCG, the time-dependent morphological alterations, and urinary cytokine release in response to intravesical BCG.
Localization (release) of BCG in urinary bladder associated with cytokine
6) Confidence 0.19 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.63 Pain Relevance 0.31
Co-localization of BCG-GFP with LRG47 in the mouse bladder urothelium
Localization (localization) of BCG in bladder
7) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0 Pain Relevance 0
For co-localization of BCG-GFP and LRG47-Rhodamine, pictures were converted to 8-bit gray scale images (fluorescence intensity range: 0 < 255) using Image J software [23] and the analysis was performed with the co-localization-finder plug-in [24].
Localization (localization) of BCG in plug
8) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0 Pain Relevance 0.03
Next, the co-localization of BCG-GFP and LRG47-Rhodamine was performed by converting the Figures 13B and 13C to 8-bit gray scale images (fluorescence intensity range: 0 < 255) using Image J software [23], assigned as red and green channels, and the analysis was performed with the co-localization-finder plug-in [24].
Localization (localization) of BCG in plug
9) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0 Pain Relevance 0
Next, we used fluorescence immunohistochemistry to demonstrate that, in our laboratory conditions, instillation of BCG-GFP does not cause any microscopic extravasation of BCG or cause artifacts, including forcing bacteria into the urothelium.
Localization (extravasation) of BCG
10) Confidence 0.15 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.15 Pain Relevance 0.03
Although this finding potentially linking BCG to axonal guidance is unique, activation of small GTPases genes by intravesical instillation of BCG into the mouse bladder was just demonstrated by our laboratory [25] and we extended the results into the present work, indicating that acute BCG does co-localize with LRG47 vesicles.
Localization (localize) of BCG in vesicles
11) Confidence 0.15 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.13 Pain Relevance 0.03
In the merged picture, presented in Figure 13D, it can be appreciated that most of background fluorescence coincides with DAPI staining (blue) whereas the BCG-GFP is co-localized in vesicles positives for LRG-47 (yellow).
Localization (localized) of BCG in vesicles
12) Confidence 0.15 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0 Pain Relevance 0
For this purpose, we used the C57BL/6 mice because our previous work already defined the time-course of bladder inflammation and urinary cytokine release in response to intravesical instillation of BCG, TNF-?
Localization (release) of BCG in bladder associated with inflammation and cytokine
13) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.75 Pain Relevance 0.27

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