INT209033

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 12.55
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
NK cells 14
T cells 6
monocytes 3
stem cells 3
lymphocytes 2
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 620 99.04 Very High Very High Very High
COX2 170 97.80 Very High Very High Very High
Inflammation 236 97.04 Very High Very High Very High
Neuropeptide 3 96.04 Very High Very High Very High
chemokine 54 91.48 High High
endometriosis 168 79.72 Quite High
Peripheral nervous system 3 76.24 Quite High
cINOD 34 68.24 Quite High
psoriasis 68 66.56 Quite High
Lasting pain 3 58.84 Quite High
Disease Link Frequency Relevance Heat
Guillain-barre Syndrome 6 100.00 Very High Very High Very High
Cancer 1306 99.98 Very High Very High Very High
Sprains And Strains 110 99.82 Very High Very High Very High
Targeted Disruption 181 99.72 Very High Very High Very High
Pneumonia 84 99.68 Very High Very High Very High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 2 99.16 Very High Very High Very High
Polyradiculoneuropathy 44 98.60 Very High Very High Very High
Demyelinating Disease 9 97.60 Very High Very High Very High
INFLAMMATION 257 97.04 Very High Very High Very High
Hypersensitivity Pneumonitis 140 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased NK cell cytotoxicity and augmented secretion of IFN-?
Positive_regulation (augmented) of Localization (secretion) of IFN in NK cell
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.50 Pain Relevance 0.15
in co-cultures with hMSCs, and further synergized with IL-2 or IL-2 and anti-CD16 mAb treated NK samples to increase the release of IFN-?
Positive_regulation (increase) of Localization (release) of IFN
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.06 Pain Relevance 0
Lysis of hMSCs by untreated and IL-2 treated NK cells is inhibited by monocytes, however, the addition of monocytes induced significant secretion of IFN-?
Positive_regulation (induced) of Localization (secretion) of IFN in NK cells
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.05 Pain Relevance 0
HMSCs are significantly more sensitive to lysis by IL-2 treated NK cells than their differentiated counterparts and they trigger significant release of IFN-?
Positive_regulation (trigger) of Localization (release) of IFN in NK cells
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.08 Pain Relevance 0
Finally, since both bevacizumab and low doses of IFN-?
Positive_regulation (since) of Localization (doses) of IFN
5) Confidence 0.49 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.53 Pain Relevance 0.05
B super-repressor in HEp2 tumors leads to significant increase in cytotoxicity and secretion of IFN-?
Positive_regulation (leads) of Localization (secretion) of IFN associated with cancer
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.99 Pain Relevance 0.21
and IL-6 secretion, we could demonstrate a direct correlation between decreased IL-6 and increased IFN-?
Positive_regulation (increased) of Localization (correlation) of IFN
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.64 Pain Relevance 0.03
HMSCs are significantly more sensitive to lysis by IL-2 treated NK cells than their differentiated counterparts and they trigger significant release of IFN-?
Positive_regulation (by) of Localization (release) of IFN in NK cells
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.08 Pain Relevance 0
B super-repressor in HEp2 tumors leads to significant increase in cytotoxicity and secretion of IFN-?
Positive_regulation (increase) of Localization (secretion) of IFN associated with cancer
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.98 Pain Relevance 0.21
Lysis of hESCs, hiPSCs, hDPSCs, and hMSCs by untreated and IL-2 treated NK cells is inhibited by anti-CD16 antibody treatment, however, the same treatment induced significant secretion of IFN-?
Positive_regulation (induced) of Localization (secretion) of IFN in NK cells
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.21 Pain Relevance 0
Phase 2 consists of recognition of bacterial antigens by CD4 lymphocytes, which release mainly IL-2 and IFN-?
Positive_regulation (mainly) of Localization (release) of IFN in lymphocytes
11) Confidence 0.49 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.49 Pain Relevance 0.28
Therefore, from these results a specific profile for NK resistant oral tumors emerged which demonstrated increased GM-CSF, IL-6 and IL-8 secretion in the context of decreased IFN-?
Positive_regulation (increased) of Localization (decreased) of IFN associated with cancer
12) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.59 Pain Relevance 0.06
For example, GCs dampen the release of IL-12, IFN-?
Positive_regulation (dampen) of Localization (release) of IFN
13) Confidence 0.49 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.32 Pain Relevance 0.33
In general, CLN HTLs from mice previously challenged with S. pneumonia strain EF3030) secreted high levels of IFN-?
Positive_regulation (levels) of Localization (secreted) of IFN in CLN associated with pneumonia and sprains and strains
14) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.45 Pain Relevance 0.04
produced by CD4+ T cells might compensate reduced amount of IFN-?
Positive_regulation (by) of Localization (amount) of IFN in T cells
15) Confidence 0.49 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.86 Pain Relevance 0.06
produced by CD4+ T cells might compensate reduced amount of IFN-?
Spec (might) Positive_regulation (compensate) of Localization (amount) of IFN in T cells
16) Confidence 0.49 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.86 Pain Relevance 0.06
Further support for the importance of IFN?
Positive_regulation (support) of Localization (importance) of IFN
17) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2841649 Disease Relevance 1.23 Pain Relevance 0.35
knock-out mice are protected from development of AIDP-like illness, implicating IFN?
Positive_regulation (protected) of Localization (implicating) of IFN associated with targeted disruption and guillain-barre syndrome
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2841649 Disease Relevance 0.70 Pain Relevance 0.20
, while a more sustained increment in release of IFN-?
Positive_regulation (increment) of Localization (release) of IFN
19) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.52 Pain Relevance 0.17
mice increased cytotoxicity and secretion of IFN-?
Positive_regulation (increased) of Localization (secretion) of IFN
20) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.27 Pain Relevance 0.24

General Comments

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