INT209088

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.26
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) molecular_function (Ceacam3) cellular_component (Ceacam3)
response to stress (Crhr1) signal transducer activity (Crhr1) biological_process (Ceacam3)
Anatomy Link Frequency
amygdala 1
Ceacam3 (Rattus norvegicus)
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 50 100.00 Very High Very High Very High
Pain 33 99.80 Very High Very High Very High
Arthritis 13 92.56 High High
antagonist 10 89.00 High High
withdrawal 8 79.72 Quite High
Visceral pain 2 56.96 Quite High
Neuropathic pain 3 46.32 Quite Low
Intracerebroventricular 1 44.48 Quite Low
Antinociceptive 2 35.12 Quite Low
opiate 1 29.92 Quite Low
Disease Link Frequency Relevance Heat
Pain 33 99.80 Very High Very High Very High
Anxiety Disorder 30 99.28 Very High Very High Very High
Arthritis 23 92.56 High High
Hypersensitivity 2 61.04 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 56.96 Quite High
Colitis 1 48.72 Quite Low
Neuropathic Pain 3 46.32 Quite Low
Hyperalgesia 2 32.96 Quite Low
Depression 5 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The novelty of this study is that it directly links the amygdala, through CRF1 receptors in the CeA, to pain-related anxiety, which is clinically well-documented but mechanistically not well understood.
CeA Binding (receptors) of CRF1 in amygdala associated with pain, anxiety disorder and amygdala
1) Confidence 0.34 Published 2007 Journal Mol Pain Section Body Doc Link PMC1891279 Disease Relevance 1.20 Pain Relevance 1.11

General Comments

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