INT209136

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.63
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
Anatomy Link Frequency
lymphocytes 2
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 150 99.98 Very High Very High Very High
agonist 25 93.04 High High
Dismenorea 1 78.12 Quite High
adenocard 4 71.60 Quite High
cytokine 97 60.24 Quite High
cINOD 3 44.80 Quite Low
fibrosis 3 12.92 Low Low
Potency 1 5.04 Very Low Very Low Very Low
antagonist 35 5.00 Very Low Very Low Very Low
chemokine 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 165 99.98 Very High Very High Very High
Asthma 317 96.88 Very High Very High Very High
Pulmonary Disease 33 92.92 High High
Dysmenorrhea 1 78.12 Quite High
Natriuresis 2 73.96 Quite High
Airway Remodeling 3 64.20 Quite High
Eczema 4 57.28 Quite High
Rhinitis 11 56.40 Quite High
Disease 24 54.92 Quite High
Targeted Disruption 22 26.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We explored in parallel the molecular mechanism of the hormonal regulation of the PDE4 expression in primary culture of myometrial cells.
Regulation (regulation) of Gene_expression (expression) of PDE4
1) Confidence 0.27 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.08 Pain Relevance 0.16
Theoretically inhibition of PDE7 may have an anti-inflammatory effect but so far this has not been demonstrated, although inhibition of PDE7 may augment the anti-inflammatory effects of PDE4 inhibition (Smith et al 2004)
Regulation (effects) of Neg (inhibition) Gene_expression (inhibition) of PDE4 associated with inflammation
2) Confidence 0.23 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.82 Pain Relevance 0.19
There are no significant differences in the expression of PDE4A, PDE4B and PDE4D in peripheral blood CD4 and CD8 lymphocytes from normal and asthmatic patients [54].
Neg (no) Regulation (differences) of Gene_expression (expression) of PDE4A in lymphocytes associated with asthma
3) Confidence 0.16 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.73 Pain Relevance 0.14

General Comments

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