INT209138

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.84
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
Anatomy Link Frequency
lung 2
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 89 98.48 Very High Very High Very High
headache 4 97.60 Very High Very High Very High
withdrawal 2 94.76 High High
adenocard 9 93.60 High High
agonist 45 90.32 High High
cytokine 25 82.72 Quite High
Onset of action 2 79.88 Quite High
Inflammatory mediators 9 76.08 Quite High
tolerance 7 74.36 Quite High
Adalimumab 2 64.52 Quite High
Disease Link Frequency Relevance Heat
Premature Birth 9 99.64 Very High Very High Very High
Emphysema 8 99.20 Very High Very High Very High
Myocardial Infarction 2 98.64 Very High Very High Very High
INFLAMMATION 108 98.48 Very High Very High Very High
Pulmonary Disease 196 98.16 Very High Very High Very High
Diarrhoea 11 98.04 Very High Very High Very High
Headache 4 97.60 Very High Very High Very High
Disease 46 96.96 Very High Very High Very High
Vomiting 22 95.72 Very High Very High Very High
Nicotine Addiction 15 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Very recently, we demonstrated that PDE4 inhibition prevents in vivo preterm delivery and fetal demise in mice [12].
Negative_regulation (prevents) of Negative_regulation (inhibition) of PDE4 associated with premature birth
1) Confidence 0.42 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.65 Pain Relevance 0.20
However, this is not consistent with the findings from a number of preclinical models indicating that PDE4 inhibitors can prevent the development of emphysema in these models (Martorana et al 2005; Leclerc et al 2006) and whilst the exact molecular target was not identified, the suppression of TNF?
Negative_regulation (prevent) of Negative_regulation (inhibitors) of PDE4 associated with emphysema
2) Confidence 0.39 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.50 Pain Relevance 0.08
A novel PDE4 inhibitor, apremilast has recently been generated [17] which has a half maximal inhibitory concentration (IC50) of 74 nM and inhibits TNF?
Negative_regulation (inhibits) of Negative_regulation (inhibitor) of PDE4
3) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911898 Disease Relevance 1.20 Pain Relevance 0.31
Elevation of intracellular cAMP, via inhibition of PDE4, triggers the protein kinase A pathway, inhibits TNF?
Negative_regulation (Elevation) of Negative_regulation (inhibition) of PDE4
4) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911898 Disease Relevance 0.87 Pain Relevance 0.45
The most recent and largely selective phosphodiesterase inhibitors, such as inhibitors of phosphodiesterase type 4 isoenzyme, slightly improve lung function in COPD (Compton et al 2001) and reduce the frequency of exacerbations (Edelson et al 2001; Rabe et al 2005; Rennard et al 2006) (see below).
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of phosphodiesterase type 4 in lung associated with pulmonary disease
5) Confidence 0.21 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 0.62 Pain Relevance 0.17

General Comments

This test has worked.

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