INT20914

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 3.41
Pain Relevance 7.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Snai1) cytoplasm (Snai1)
Anatomy Link Frequency
heart 3
nerve 2
neurons 1
nitrergic neurons 1
BAT 1
Snai1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 20 100.00 Very High Very High Very High
Intracerebroventricular 16 99.66 Very High Very High Very High
halothane 14 99.64 Very High Very High Very High
narcan 32 99.40 Very High Very High Very High
Catecholamine 19 99.40 Very High Very High Very High
Rostral ventrolateral medulla 19 98.94 Very High Very High Very High
Raphe 4 98.38 Very High Very High Very High
medulla 6 98.12 Very High Very High Very High
Morphine 16 97.08 Very High Very High Very High
anesthesia 9 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 48 100.00 Very High Very High Very High
Volume Depletion And Dehydration 2 92.88 High High
Pressure Volume 2 Under Development 3 88.72 High High
Hemorrhage 2 76.16 Quite High
Fever 8 75.00 Quite High
Depression 1 73.36 Quite High
Hypertension 1 72.72 Quite High
Heart Rate Under Development 1 72.04 Quite High
Nociception 1 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A pronounced immediate increase in adrenal SNA occurs in parallel with renal SNA inhibition.
Positive_regulation (increase) of SNA
1) Confidence 0.41 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2160005 Disease Relevance 0.14 Pain Relevance 0.51
The data suggest that nitrergic neurons within the PVN and, to a lesser extent, in the NTS, some of which project to the RVLM, may contribute to the central pathways influencing SNA elicited by cardiac mechanoreceptor stimulation.
Positive_regulation (elicited) of SNA in nitrergic neurons associated with rostral ventrolateral medulla
2) Confidence 0.40 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16682470 Disease Relevance 0 Pain Relevance 0.33
Although renal SNA was inhibited by approximately 50%, adrenal SNA and lumbar SNA increased by approximately 400 and 80%, respectively.
Positive_regulation (increased) of SNA
3) Confidence 0.37 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2187076 Disease Relevance 0 Pain Relevance 0.83
Although renal SNA was inhibited by approximately 50%, adrenal SNA and lumbar SNA increased by approximately 400 and 80%, respectively.
Positive_regulation (increased) of SNA
4) Confidence 0.37 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2187076 Disease Relevance 0 Pain Relevance 0.83
Hypothalamic stimulation also increased postganglionic AdSNA by 42-113% and renal sympathetic nerve activity by 94-171%.
Positive_regulation (increased) of AdSNA in nerve
5) Confidence 0.37 Published 2010 Journal Exp. Physiol. Section Abstract Doc Link 19700518 Disease Relevance 0 Pain Relevance 0.30
Prior inhibition of neurons in the dorsomedial hypothalamus eliminated the intracerebroventricular fentanyl-evoked increases in BAT SNA, BAT temperature, and HR, but not those in RSNA or AP.
Positive_regulation (increases) of SNA in BAT associated with obesity and intracerebroventricular
6) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.97 Pain Relevance 0.57
Increases in brown adipose tissue (BAT) sympathetic nerve activity (SNA) (peak, +326% of control), BAT temperature (peak, +0.8 degrees C), renal SNA (peak, +146% of control), and heart rate (HR; peak, +32 beats/min) produced by intravenous fentanyl were abolished by premamillary transection of the neuraxis but were mimicked by intracerebroventricular administration of fentanyl, which also increased arterial pressure (AP; peak, +12 mmHg).
Positive_regulation (Increases) of SNA in heart associated with obesity and intracerebroventricular
7) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.50 Pain Relevance 0.33
Increases in brown adipose tissue (BAT) sympathetic nerve activity (SNA) (peak, +326% of control), BAT temperature (peak, +0.8 degrees C), renal SNA (peak, +146% of control), and heart rate (HR; peak, +32 beats/min) produced by intravenous fentanyl were abolished by premamillary transection of the neuraxis but were mimicked by intracerebroventricular administration of fentanyl, which also increased arterial pressure (AP; peak, +12 mmHg).
Positive_regulation (Increases) of SNA in heart associated with obesity and intracerebroventricular
8) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.45 Pain Relevance 0.28
Microinjection of glycine (0.5 M, 60 nl) to inhibit local neurons in the rostral raphe pallidus (RPa) selectively reversed the intracerebroventricular fentanyl-evoked increases in BAT SNA and HR, while the fentanyl-evoked excitation in RSNA, the pressor responses, and the tachycardic responses were reversed by inhibition of neurons in the rostral ventrolateral medulla (RVLM).
Positive_regulation (increases) of SNA in neurons associated with rostral ventrolateral medulla, obesity, intracerebroventricular and raphe
9) Confidence 0.36 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.73 Pain Relevance 0.56
Both non-noxious and noxious thermal sensory stimulation above 36 degrees C caused a parallel increase in NE-LC firing rate and NE-SNA, changes that were accompanied by increases in arterial blood pressure and heart rate.
Positive_regulation (increase) of NE-SNA in heart associated with locus ceruleus
10) Confidence 0.27 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697682 Disease Relevance 0.06 Pain Relevance 0.28
In contrast, an increase in NE-SNA remained throughout the stimulation period.
Positive_regulation (increase) of NE-SNA
11) Confidence 0.27 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697682 Disease Relevance 0.17 Pain Relevance 0.41
To examine whether feedforward control by central command activates preganglionic adrenal sympathetic nerve activity (AdSNA) and releases catecholamines from the adrenal medulla, we investigated the effects of electrical stimulation of the hypothalamic locomotor region on preganglionic AdSNA and secretion rate of adrenal catecholamines in anaesthetized rats.
Spec (whether) Positive_regulation (activates) of AdSNA in nerve associated with medulla and catecholamine
12) Confidence 0.25 Published 2010 Journal Exp. Physiol. Section Abstract Doc Link 19700518 Disease Relevance 0 Pain Relevance 0.18
Hypothalamic stimulation for 30 s (50 Hz, 100-200 microA) induced rapid activation of preganglionic AdSNA by 83-181% depending on current intensity, which was followed by an immediate increase of 123-233% in adrenal adrenaline output.
Positive_regulation (activation) of AdSNA
13) Confidence 0.25 Published 2010 Journal Exp. Physiol. Section Abstract Doc Link 19700518 Disease Relevance 0 Pain Relevance 0.27
This was paralleled by slight increases in rSNA and MAP.
Positive_regulation (increases) of rSNA
14) Confidence 0.24 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3250217 Disease Relevance 0.07 Pain Relevance 0.60
However, pretreatment with (-)naloxone (2 or 15 mg.kg-1) induced an increase in rSNA at 0.6% halothane, and subsequently the rSNA inhibition was less pronounced at the two higher halothane concentrations compared with control.
Positive_regulation (increase) of rSNA associated with narcan and halothane
15) Confidence 0.24 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2913865 Disease Relevance 0.32 Pain Relevance 1.43

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