INT209140

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 54 92.24 High High
agonist 28 74.64 Quite High
antagonist 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 62 92.24 High High
Hypertension 7 70.04 Quite High
Reprotox - General 2 4 68.92 Quite High
Heart Disease 1 68.04 Quite High
Targeted Disruption 2 38.40 Quite Low
Disease 7 29.20 Quite Low
Nicotine Addiction 3 22.72 Low Low
Pulmonary Disease 31 21.68 Low Low
Premature Birth 14 5.00 Very Low Very Low Very Low
Vomiting 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, cAMP- and hormonal-sensitive promoters control the transcription of some of the PDE4 short-forms, leading to a decrease in cAMP levels after a sustained elevation of the cyclic nucleotide content.
Transcription (transcription) of PDE4
1) Confidence 0.71 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.28 Pain Relevance 0.04
RT-PCR experiments and PDE4 activity measurement were performed in order to assess some of the mechanisms that could be involved in desensitization process and we found that neither ADRB2 and ADRB3 mRNA expression levels nor PDE4 activity were affected by salbutamol or SR 59119A treatments.


Transcription (expression) of PDE4
2) Confidence 0.38 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
There are significant differences in the tissue distribution of the mRNA for the PDE4 isoforms (Table 1).
Transcription (distribution) of PDE4
3) Confidence 0.31 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.31 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox