INT209144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.03
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4B) signal transduction (PDE4B) nucleus (PDE4B)
cytoplasm (PDE4B)
Anatomy Link Frequency
macrophages 1
PDE4B (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 15 100.00 Very High Very High Very High
cytokine 16 99.04 Very High Very High Very High
Inflammation 86 95.56 Very High Very High Very High
Inflammatory response 4 56.56 Quite High
Inflammatory mediators 7 46.00 Quite Low
Dismenorea 3 37.32 Quite Low
adenocard 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 99.38 Very High Very High Very High
Nicotine Addiction 3 99.16 Very High Very High Very High
Pulmonary Disease 31 98.64 Very High Very High Very High
INFLAMMATION 98 95.56 Very High Very High Very High
Hypertension 11 79.16 Quite High
Reprotox - General 2 8 78.04 Quite High
Premature Birth 27 71.60 Quite High
Dysmenorrhea 3 37.32 Quite Low
Vomiting 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upregulated by the proinflammatory cytokine IL-1?.
Positive_regulation (induced) of PDE4B2 associated with agonist and cytokine
1) Confidence 0.45 Published 2007 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC1892053 Disease Relevance 0.60 Pain Relevance 0.28
, by increasing PGE2concentration, is also able to induce PDE4B2 [10].
Positive_regulation (induce) of PDE4B2
2) Confidence 0.39 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.10 Pain Relevance 0.16
Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upregulated by the proinflammatory cytokine IL-1?.
Positive_regulation (upregulated) of PDE4B2 associated with agonist and cytokine
3) Confidence 0.30 Published 2007 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC1892053 Disease Relevance 0.74 Pain Relevance 0.35
Changes in isoforms may occur in disease and it has been reported that PDE4A4B is upregulated in macrophages from smokers with COPD (Barber et al 2004).
Positive_regulation (upregulated) of PDE4A4B in macrophages associated with pulmonary disease, nicotine addiction and disease
4) Confidence 0.12 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.60 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox