INT209191

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.05
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (LHCGR) endoplasmic reticulum (LHCGR) cytoplasm (LHCGR)
signal transducer activity (LHCGR) extracellular space (LHCGR) nucleus (LHCGR)
LHCGR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 10 50.24 Quite High
antagonist 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 10 50.24 Quite High
Premature Birth 6 5.00 Very Low Very Low Very Low
Anencephaly 4 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is no clear what targets are phosphorylated by PRKA upon stimulation of the LHCGR but the available evidence suggest that hCG antagonises proteins involved in oxytocin signalling [45].
Positive_regulation (stimulation) of LHCGR
1) Confidence 0.28 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.05 Pain Relevance 0.05
Moreover, activation of LHCGR in human myometrial cells leads to loss of gap junction formation and downregulation of GJA1 protein by a PRKA mediated effect [46].
Positive_regulation (activation) of LHCGR
2) Confidence 0.28 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0

General Comments

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