INT209218

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Dlg1) plasma membrane (Dlg1) nucleus (Dlg1)
cytoplasm (Dlg1)
Anatomy Link Frequency
synapse 1
Dlg1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 26 99.34 Very High Very High Very High
Hippocampus 40 92.80 High High
Glutamate 119 86.92 High High
long-term potentiation 57 57.84 Quite High
Neurotransmitter 10 50.00 Quite Low
Catecholamine 20 41.20 Quite Low
chemokine 9 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 1 97.28 Very High Very High Very High
Death 14 92.32 High High
Stress 26 91.56 High High
Nervous System Malformation 8 76.40 Quite High
Targeted Disruption 82 59.28 Quite High
Adhesions 8 45.60 Quite Low
Anaerobic Bacterial Infections 2 8.12 Low Low
Pheochromocytoma 32 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Aging 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed increases in gene expression for the synaptic membrane scaffold proteins (Dlg1, Dlg2, and Dlg4), and a protein involved in synapse strengthening (Arc, Activity-Regulated Cytoskeleton-Associated Protein), also fit a pattern of new synapse growth.
Gene_expression (expression) of Dlg1 in synapse associated with aids-related complex
1) Confidence 0.54 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.42 Pain Relevance 0.28
Significant changes in protein levels of NMDA receptor subunits NR1 and NR2A, and NMDA receptor interacting proteins PSD-95 and SAP97 were not detected.
Neg (not) Gene_expression (detected) of SAP97 associated with nmda receptor
2) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0.37
Significant changes in protein levels of NMDA receptor subunits NR1 and NR2A, and NMDA receptor interacting proteins PSD-95 and SAP97 were not detected.
Neg (not) Gene_expression (detected) of SAP97 associated with nmda receptor
3) Confidence 0.23 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0.37

General Comments

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