INT209221

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.81
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
neurons 4
hippocampus 4
cerebellum 4
perirhinal cortex 2
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 469 100.00 Very High Very High Very High
Dorsal horn 46 99.84 Very High Very High Very High
Hippocampus 224 99.68 Very High Very High Very High
Pain 21 99.44 Very High Very High Very High
Morphine 231 98.60 Very High Very High Very High
Nicotine 3 98.26 Very High Very High Very High
Spinal cord 36 98.24 Very High Very High Very High
Central nervous system 33 96.80 Very High Very High Very High
Inflammation 9 92.48 High High
cINOD 3 90.96 High High
Disease Link Frequency Relevance Heat
Aging 342 100.00 Very High Very High Very High
Pain 62 99.44 Very High Very High Very High
Targeted Disruption 164 99.06 Very High Very High Very High
Pathologic Processes 6 96.36 Very High Very High Very High
Cognitive Disorder 75 95.76 Very High Very High Very High
INFLAMMATION 12 92.48 High High
Drug Dependence 45 87.56 High High
Stress 7 65.20 Quite High
Disease 24 41.04 Quite Low
Cerebellar Diseases 3 20.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The VMIC value (-48 mV in this example) is also intermediate between the VMIC values of NR2A/B and NR2C/D subunits, supporting the interpretation that the NMDA receptors expressed by this NK1R+ neuron are heterogeneous in NR2 subtype expression.
Regulation (heterogeneous) of Gene_expression (expression) of NR2 in neuron associated with nmda receptor
1) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.26
In the present study, we examined whether PSD-93 deficiency affected synaptic NR2A and NR2B expression in two major pain-related regions [18,19], spinal cord and forebrain cortex, and a motor and coordination-related region [20], cerebellum, of the CNS.
Spec (whether) Regulation (affected) of Gene_expression (expression) of NR2A in cerebellum associated with pain, central nervous system and spinal cord
2) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.75 Pain Relevance 0.53
Blunted NMDAR-dependent neuronal plasticity following repeated morphine injection in PSD-93 KO mice is attributed to PSD-93 deletion-induced alterations of NR2A and NR2B postsynaptic expression in dorsal horn and forebrain cortex neurons, but not in cerebellar neurons.
Regulation (alterations) of Gene_expression (expression) of NR2A in neurons associated with targeted disruption, dorsal horn and morphine
3) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.75 Pain Relevance 1.23
Immunoblot analysis showed that PSD-93 deletion did not alter expression of NR2A and NR2B in total soluble fractions from dorsal horn, forebrain cortex, or cerebellum of mice (Fig. 1A), a finding consistent with those in previous studies [16,21,30].
Neg (not) Regulation (alter) of Gene_expression (expression) of NR2A in cerebellum associated with dorsal horn
4) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.13 Pain Relevance 0.12
There was also a significant increase in GluN1 in the perirhinal cortex, but no effect on GluN2A subunit expression in any region examined (Fontan-Lozano et al., 2007).
Neg (no) Spec (examined) Regulation (effect) of Gene_expression (expression) of GluN2A subunit in perirhinal cortex
5) Confidence 0.21 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.32 Pain Relevance 0.15
There is little or no effect of aging on the mRNA expression of the GluN2A subunit in the cortex or hippocampus of C57Bl/6 mice (Magnusson, 2000, 2001; Magnusson et al., 2006).
Neg (little) Regulation (effect) of Gene_expression (expression) of GluN2A subunit in hippocampus associated with aging and hippocampus
6) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.42 Pain Relevance 0.27
Nicotine reversed the effects of aging on the GluN2B subunit in the hippocampus, but showed no influence on expression of the GluN2A subunit in aged Sprague-Dawley rats (Delibas et al., 2005).
Neg (no) Regulation (influence) of Gene_expression (expression) of GluN2A subunit in hippocampus associated with aging, nicotine and hippocampus
7) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.44 Pain Relevance 0.50
Significant changes in protein levels of NMDA receptor subunits NR1 and NR2A, and NMDA receptor interacting proteins PSD-95 and SAP97 were not detected.
Regulation (changes) of Gene_expression (levels) of NR2A associated with nmda receptor
8) Confidence 0.12 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0.39

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