INT209224

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.22
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Dlg1) plasma membrane (Dlg1) nucleus (Dlg1)
cytoplasm (Dlg1)
Anatomy Link Frequency
synapse 1
Dlg1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 17 88.84 High High
IPN 9 72.88 Quite High
Glutamate receptor 24 61.20 Quite High
imagery 3 55.92 Quite High
Spinal sensitization 1 54.84 Quite High
long-term potentiation 33 48.96 Quite Low
central sensitization 9 47.76 Quite Low
Neuropathic pain 4 13.60 Low Low
Kinase C 19 11.08 Low Low
Hippocampus 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 12 85.80 High High
Inflammatory Pain 9 72.88 Quite High
Aids-related Complex 2 58.48 Quite High
Schizophrenia 13 50.00 Quite Low
Pheochromocytoma 16 45.92 Quite Low
Mental Disorders 1 19.36 Low Low
Hyperalgesia 5 15.68 Low Low
Cognitive Disorder 1 14.40 Low Low
Neuropathic Pain 4 13.60 Low Low
Nociception 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After blocking nonspecific protein interactions with 10% albumin in Tris-buffered saline (TBS), the nitrocellulose papers were incubated for 2 hr at room temperature with the primary antibodies: NR1 (1:1000; Pharmingen, San Diego, CA, USA), NR2A (1:1000; Zymed, San Francisco, CA, USA), NR2B (1:1000; Zymed), GluR1 (1:1500; Chemicon, Temecula, CA, USA), PSD-95 (1:2000; Affinity BioReagents, Golden, CO, USA), SAP97 (1:1000; StressGen, San Diego, CA, USA), Ca2+/calmodulin-dependent protein kinase II (?
SAP97 Neg (blocking) Binding (blocking) of
1) Confidence 0.13 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0.05
PSD-95 expression affects AMPA receptor-mediated excitatory synaptic transmission (Migaud et al, 1998; Beique et al, 2006; Carlisle et al, 2008) and is thought to involve indirect interactions through stargazin, SAP-97, Adam22, Lgi1 and Nsf (Leonard et al, 1998; Osten et al, 1998; Fukata et al, 2006).
SAP-97 Binding (interactions) of
2) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.14 Pain Relevance 0.08
Another PDZ domain protein, synapse-associated protein 97 (SAP 97) binds to the C-terminus of GluR1 subunit and interacts with the actin-associated protein 4.1N (which can also bind GluR1 subunit).
SAP 97 Binding (binds) of in synapse
3) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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