INT20925

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Context Info
Confidence 0.01
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 4.20
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ANTXR1)
Anatomy Link Frequency
skin 2
neuronal 1
pore 1
soma 1
neural 1
ANTXR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 30 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
gABA 6 99.20 Very High Very High Very High
Morphine 8 99.12 Very High Very High Very High
adenocard 1 97.64 Very High Very High Very High
opioid receptor 4 97.40 Very High Very High Very High
Calcium channel 6 96.68 Very High Very High Very High
Antihistamine 4 96.28 Very High Very High Very High
tetrodotoxin 169 94.32 High High
agonist 9 91.68 High High
Disease Link Frequency Relevance Heat
Vibrio Infection 138 100.00 Very High Very High Very High
Bordatella Infection 13 100.00 Very High Very High Very High
Diphtheria 7 93.74 High High
Cancer 33 82.84 Quite High
Stress 12 81.68 Quite High
Depression 1 79.40 Quite High
INFLAMMATION 12 70.52 Quite High
Metastasis 1 64.68 Quite High
Disease 30 52.20 Quite High
Stroke 18 51.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the functional opioid-like activity of the anti-opioid receptor IgG was demonstrated by their ability to inhibit adenylate cyclase activity by a Gi/o-protein-mediated mechanism as indicated by abrogation of the effect by either opioid antagonist or pertussis toxin.
pertussis toxin Binding (abrogation) of associated with bordatella infection, antagonist, opioid receptor and opioid
1) Confidence 0.01 Published 1999 Journal Eur. J. Immunol. Section Abstract Doc Link 10092104 Disease Relevance 0.10 Pain Relevance 0.90
The collective data from the skin and the airways prompted a number of questions regarding toxin-allergen interactions.
toxin Binding (interactions) of in skin
2) Confidence 0.01 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0.05 Pain Relevance 0.08
Allergen–toxin interactions.
toxin Binding (interactions) of
3) Confidence 0.01 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0.07 Pain Relevance 0.14
Thus the antipropulsive effect of central morphine could be initiated at receptor sites which interact with G-protein substrates of pertussis toxin.
pertussis toxin Binding (interact) of associated with bordatella infection and morphine
4) Confidence 0.01 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2160368 Disease Relevance 0.31 Pain Relevance 0.49
Their interactions with multiple P loops also strongly supported the conclusion that toxin occludes the pore and interacts with residues critical for permeation and selectivity.
toxin Binding (interacts) of in pore
5) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.62
Conformational changes during toxin binding would imply the existence of several stages in the binding process.
toxin Binding (binding) of
6) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.34
In the skin, a similar relation between lipid rafts recognized by cholera toxin and cell maturity has been reported.
cholera toxin Binding (recognized) of in skin associated with vibrio infection
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.50 Pain Relevance 0
Consistent with previous work from other labs [27], [28], [31], our work suggests that NSCs exhibit little Cholera toxin B subunit binding.
Cholera toxin B Binding (binding) of associated with vibrio infection
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.24 Pain Relevance 0.07
Consistent with this previous study, we find that cultured NSCs exhibit low levels of Cholera toxin B subunit binding, but we also do caution here of the need to perform ganglioside expression studies carefully.
Cholera toxin B Binding (binding) of associated with vibrio infection
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.18 Pain Relevance 0
Cholera toxin is comprised of 5 copies of the B subunit that bind to GM1+ gangliosides on lipid rafts, and a single copy of the A subunit that enters the cell via endocytosis, subsequently increasing cAMP levels.
Cholera toxin Binding (bind) of associated with vibrio infection
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.62 Pain Relevance 0.08
Stem-like cells in the skin show little cholera toxin binding, whereas more differentiated, transit amplifying cells are enriched in lipid rafts [36], strongly correlating to the neural cells reported here.
cholera toxin Binding (binding) of in neural associated with vibrio infection
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.55 Pain Relevance 0
Fluorescence-conjugated Cholera toxin B subunit (CholB) recognizes GM1+ gangliosides on lipid rafts and can be used to label cells differentiating towards the neuronal lineage [27], [28], [29].
Cholera toxin B Binding (recognizes) of in neuronal associated with vibrio infection
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.64 Pain Relevance 0
Diphtheria toxin is secreted from Corynebacterium diphtheriae as a single polypeptide chain containing two major domains: A chain (amino-terminal, 193 residues), which carries the active site for adenosine diphosphate (ADP)-ribosylation of elongation factor-2, and B chain (carboxyl-terminal, 342 residues), which promotes binding of toxin to cells and the entry of the A chain into the cytosolic compartment.
toxin Binding (binding) of associated with adenocard and diphtheria
13) Confidence 0.00 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.65 Pain Relevance 0.05
SCH-202676 had no direct effect on G protein activity as assessed by [35S]guanosine-5'-O-(gamma-thio)triphosphate binding to purified recombinant G(oalpha)- or G(betagamma)-stimulated ADP-ribosylation of G(oalpha) by pertussis toxin.
pertussis toxin Binding (binding) of associated with bordatella infection
14) Confidence 0.00 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.10 Pain Relevance 0.41
The inhibition of GABA release by baclofen was abolished by a pretreatment with pertussis toxin (PTX), whereas the inhibition of whole-cell calcium currents by baclofen was only partially depressed by PTX, suggesting that G-protein mechanisms involved in GABAB receptor modulation at the soma and axon terminal may not be identical.
pertussis toxin Binding (pretreatment) of in soma associated with gaba and bordatella infection
15) Confidence 0.00 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9465016 Disease Relevance 0.18 Pain Relevance 0.64

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