INT209257

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.16
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SUB1) nucleus (SUB1) DNA binding (SUB1)
Anatomy Link Frequency
Epidermis 2
SUB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 4 72.72 Quite High
Inflammation 2 61.12 Quite High
Peripheral nervous system 2 50.16 Quite High
qutenza 12 50.00 Quite Low
diabetic neuropathy 16 44.84 Quite Low
dorsal root ganglion 64 44.08 Quite Low
member 8 1 18.40 Low Low
Pain 34 5.00 Very Low Very Low Very Low
Spinal cord 22 5.00 Very Low Very Low Very Low
Nerve growth factor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 50 100.00 Very High Very High Very High
Liver Cancer 4 97.64 Very High Very High Very High
Autism 148 90.88 High High
INFLAMMATION 7 61.12 Quite High
Stress 7 58.32 Quite High
Peripheral Neuropathy 2 46.08 Quite Low
Diabetic Neuropathy 16 44.84 Quite Low
Ganglion Cysts 66 44.08 Quite Low
Neuropathic Pain 30 40.28 Quite Low
Injury 40 25.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ALDH3B1, RPS9, SUB1, and VPS25 also were negatively correlated with Hg in TD subjects in this study and were downregulated in Hg-treated yeast (Jin et al. 2008).
Negative_regulation (downregulated) of SUB1
1) Confidence 0.05 Published 2009 Journal Neurotox Res Section Body Doc Link PMC3006666 Disease Relevance 0.79 Pain Relevance 0.10
Comparison of the ratio of TRPV1 with either neuronal marker showed a significant decrease in diabetic sub-epidermis [TRPV1: peripherin median (range): controls 2.2 (0.7–4.2); diabetic 0.6 (0–1.3) p < 0.01; TRPV1: neurofilament median (range): controls 1.05 (0.44–1.75); diabetic 0.14 (0.04–0.38) p < 0.01; Fig 10B,C] indicating a decrease of TRPV1 immunoreactivity preceding the decrease in innervation.
Negative_regulation (decrease) of sub in epidermis associated with diabetes mellitus
2) Confidence 0.01 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.81 Pain Relevance 0.03
In diabetes, counts of TRPV1 immunoreactive fibres per mm length of tissue section showed a significant decrease in both epidermis and sub-epidermis [median (range) Epidermis: control 1.2 (0.0–2.6), diabetic 0.0 (0.0–0.6); p < 0.01; Sub-epidermis: control 4.4 (0.2–11.1), diabetic 0.4 (0.0–3.4); p < 0.01; Fig 9A,B].
Negative_regulation (decrease) of sub in Epidermis associated with diabetes mellitus
3) Confidence 0.01 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.56 Pain Relevance 0

General Comments

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