INT209258

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 3.30
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SUB1) nucleus (SUB1) DNA binding (SUB1)
Anatomy Link Frequency
stigma 1
skin 1
SUB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diabetic neuropathy 8 99.74 Very High Very High Very High
dorsal root ganglion 32 95.44 Very High Very High Very High
Anterior cingulate cortex 37 94.76 High High
Spinal cord 11 83.96 Quite High
qutenza 6 75.00 Quite High
Dorsal horn 1 72.80 Quite High
Pain 44 72.40 Quite High
Nerve growth factor 6 41.44 Quite Low
alcohol 16 25.00 Low Low
tolerance 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 8 99.74 Very High Very High Very High
Disease 7 96.68 Very High Very High Very High
Injury 25 96.32 Very High Very High Very High
Ganglion Cysts 33 95.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 62 92.80 High High
Diabetes Mellitus 30 90.72 High High
Neuropathic Pain 15 90.00 High High
Influenza Virus Infection 122 86.88 High High
Sprains And Strains 45 78.80 Quite High
Nervous System Injury 9 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of this information, CYP4BL transcript expression was measured in all G. ventalina, P. homomalla and control-fed snails with general-cyp4BL primers, and the data were reanalyzed excluding Shark Rock reef, which contained snails with negligible CYP4BL(sub A) transcript expression levels.
Gene_expression (expression) of sub
1) Confidence 0.75 Published 2010 Journal BMC Ecol Section Body Doc Link PMC3022543 Disease Relevance 0 Pain Relevance 0
However, all three of these snails did express transcripts detected by subset-specific CYP4BL(sub B) primers at levels comparable to other snails feeding on the same diet, indicating that other CYP4BL subfamily transcripts were being expressed.
Gene_expression (expressed) of sub
2) Confidence 0.75 Published 2010 Journal BMC Ecol Section Body Doc Link PMC3022543 Disease Relevance 0 Pain Relevance 0
ANOVA analysis further revealed that the significant Diet × Reef interaction could be traced to differences in CYP4BL(sub A) transcript expression among reefs.
Gene_expression (expression) of sub
3) Confidence 0.75 Published 2010 Journal BMC Ecol Section Body Doc Link PMC3022543 Disease Relevance 0 Pain Relevance 0
However, CYP4 transcript expression was still significantly induced in snails feeding on P. homomalla: CYP4BK, CYP4BL and CYP4BL(sub A) transcript expression levels were 2.7--5.1-fold greater in C. gibbosum feeding on P. homomalla as compared to controls (MANOVA/ANOVA, P < 0.001, 7b and Additional files 13 and 14).


Gene_expression (expression) of sub
4) Confidence 0.75 Published 2010 Journal BMC Ecol Section Body Doc Link PMC3022543 Disease Relevance 0 Pain Relevance 0
Following this safety trial, a Phase II/III randomised, observer-blind, controlled study was conducted to assess the safety and immunogenicity of Sub/MF59™ in a large cohort of elderly (?
Gene_expression (/) of Sub
5) Confidence 0.65 Published 2008 Journal Immun Ageing Section Body Doc Link PMC2291031 Disease Relevance 0.59 Pain Relevance 0
Normans out of thirteen feeding on G. ventalina, and one snail collected from Shark Rock out of eleven feeding on P. homomalla, showed negligible expression of CYP4BL(sub A) transcripts, accounting for the significance of the interaction term.
Gene_expression (expression) of sub
6) Confidence 0.65 Published 2010 Journal BMC Ecol Section Body Doc Link PMC3022543 Disease Relevance 0 Pain Relevance 0
Following this safety trial, a Phase II/III randomised, observer-blind, controlled study was conducted to assess the safety and immunogenicity of Sub/MF59™ in a large cohort of elderly (?
Gene_expression (safety) of Sub
7) Confidence 0.65 Published 2008 Journal Immun Ageing Section Body Doc Link PMC2291031 Disease Relevance 0.60 Pain Relevance 0
By framing risky behaviors as a concern for the patient's own health as well as transmission to others, Positive Choice reduced potential stigma and avoided conceptualizing the individual simply as a vector of disease.
Gene_expression (reduced) of Positive Choice in stigma associated with disease
8) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2292251 Disease Relevance 0.66 Pain Relevance 0
In the present study, we used a three-step multiple source analysis to find cortical sources responsible for evoked potentials in the 0.1 Hz condition: 2 Hz, Sub1 (0.5 Hz-2 Hz) and Sub2 (0.1 Hz-0.5 Hz).
Spec (find) Gene_expression (sources) of Sub1
9) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2607283 Disease Relevance 0.07 Pain Relevance 0.15
In diabetic neuropathy skin, TRPV1 expressing sub- and intra-epidermal fibres were decreased, as was expression in surviving fibres.
Gene_expression (expressing) of sub in skin associated with diabetic neuropathy
10) Confidence 0.02 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 1.38 Pain Relevance 0.55

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