INT209261

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.58
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
microglia 1
Mpz (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 94.08 High High
Potency 1 93.48 High High
Neuronal excitability 1 77.28 Quite High
Pyramidal cell 11 72.48 Quite High
Locus ceruleus 3 68.44 Quite High
Catecholamine 1 64.48 Quite High
Inflammatory mediators 7 63.88 Quite High
Inflammation 37 50.00 Quite Low
Nucleus accumbens 6 36.24 Quite Low
ischemia 2 33.12 Quite Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 28 100.00 Very High Very High Very High
Death 49 93.24 High High
Parkinson's Disease 86 92.00 High High
Disease 128 84.56 Quite High
Shock 4 65.72 Quite High
INFLAMMATION 47 63.48 Quite High
Stress 19 63.32 Quite High
Toxicity 18 58.40 Quite High
Apoptosis 8 55.52 Quite High
Cv Unclassified Under Development 2 33.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, in both neuronal cell types, the treatment with MPP+ induced an increase in the phosphorylation at Tyr216 of GSK-3?
MPP Binding (treatment) of in neuronal
1) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.67 Pain Relevance 0
On the one hand, neuromelanin can bind MPP+ (D'Amato et al., 1986) and paraquat (Lindquist et al., 1988), reducing their neurotoxicity, and accumulate dopaminergic drugs, regulating their intracellular concentration (Salazar et al., 1978).
MPP Binding (bind) of associated with drug induced neurotoxicity
2) Confidence 0.10 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.28 Pain Relevance 0.07
SN also suppresses MPP+-induced neurotoxicity by inhibition of microglia activation
MPP+-induced Binding (neurotoxicity) of in microglia associated with drug induced neurotoxicity
3) Confidence 0.09 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.63 Pain Relevance 0.08
It's interesting there is a fraction of TRPC5 that remains intracellular at both P0 and P48.
P0 Binding (intracellular) of
4) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.30

General Comments

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