INT209286

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.24
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
neural 1
Trpc5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 207 92.48 High High
Hippocampus 48 63.52 Quite High
Action potential 6 62.04 Quite High
agonist 9 57.20 Quite High
depression 2 56.24 Quite High
Pyramidal cell 22 37.56 Quite Low
Neuronal excitability 2 35.36 Quite Low
Glutamate receptor 2 27.84 Quite Low
Potency 5 9.68 Low Low
imagery 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 39 99.98 Very High Very High Very High
Kidney Stones 16 95.80 Very High Very High Very High
Hypercalcemia 1 61.60 Quite High
Hematuria 1 60.48 Quite High
Death 7 60.36 Quite High
Depression 2 56.24 Quite High
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This procedure produces a reduction in the TRPC5 ?
Negative_regulation (reduction) of TRPC5
1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.09
Furthermore, we observed a substantial reduction in the dADP amplitude in response to PKC activation which is consistent with the report that in HEK cells, TRPC5 channels are desensitized by PKC phosphorylation of T972 located in the C-terminal region [44],[45],[46].
Negative_regulation (desensitized) of TRPC5
2) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.06 Pain Relevance 0.14
Otherwise the presence or absence of TRPC5 and TRPC6 in association with TRPC1 may help to explain bFGF-activated current changes during the neuronal differentiation from A2B5+ NPCs possibly via formation of different heteromeric TRPC complexes such as heteromeric TRPC (1+5) and TRPC (1+3+5) channels as described previously [10].
Negative_regulation (absence) of TRPC5 in neuronal associated with trp channel
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.21 Pain Relevance 0.34
On the other hand, down-regulation of either TRPC5 or TRPC6 or both of them using siRNA significantly suppressed neuronal differentiation of the A2B5+ NPCs in the differentiation condition (Figure 6B).
Negative_regulation (regulation) of TRPC5 in neuronal
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.03
Significantly, knock-down of TRPC5 resulted in inhibition of TG-stimulated Ba2+ influx in cell in the differentiation media (Fig. 7D, 0.10±0.04, n?
Negative_regulation (down) of TRPC5 associated with targeted disruption
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.24 Pain Relevance 0
Moreover, single cell RT-PCR proved knockdown of TRPC5 and TRPC6 (Figure 7A -C).
Negative_regulation (knockdown) of TRPC5
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.06 Pain Relevance 0
Knockdown of TRPC5 attenuates SOCE and neural differentiation of the A2B5+ NPCs in the differentiation conditions
Negative_regulation (Knockdown) of TRPC5 in neural
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.06 Pain Relevance 0.10
We previously reported that the down-regulation of transient receptor potential vanilloid 5 (TRPV5), sodium-hydrogen exchanger 3 (NHE3), sodium-glucose cotransporter 1 (SGLT1), and sodium-potassium-chloride cotransporter type 2 (NKCC2) is associated with hypercalciuria and that thiazides decreased calcium excretion by 50% in hypercalciuric rats induced by high salt or high calcium diet (12).
Negative_regulation (regulation) of transient receptor potential vanilloid 5 associated with kidney stones
8) Confidence 0.13 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.62 Pain Relevance 0

General Comments

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